Evidence map›Paper›PMID 34977869›Full record

ReviewMedComm2021

Nasally inhaled therapeutics and vaccination for COVID-19: Developments and challenges.

Jinxiang Xi, Lameng Ray Lei, William Zouzas, Xiuhua April Si

Open access · goldAbstract readReview
In one paragraph

Review in MedComm, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Viral Live-Attenuated Vaccines (LAVs): Past and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Chitosan non-particulate vaccine delivery systems.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024
    Review
  12. Article
  13. Construction and application of adenoviral vectors.Molecular therapy. Nucleic acids · 2023
    Review
  14. Aerosol pulmonary immune engineering.Advanced drug delivery reviews · 2023
    Review
  15. Article
  16. Nasal sprays for treating COVID-19: a scientific note.Pharmacological reports : PR · 2023
    Review
  17. Carrageenan fromBiosensors · 2023
    Article
  18. Recent advances in respiratory immunization: A focus on COVID-19 vaccines.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jinxiang XiDepartment of Biomedical Engineering University of Massachusetts Lowell Massachusetts USA.
Lameng Ray LeiAmphastar Pharmaceuticals, Inc Rancho Cucamonga California USA.
William ZouzasDepartment of Biomedical Engineering University of Massachusetts Lowell Massachusetts USA.
Xiuhua April SiDepartment of Aerospace Industrial and Mechanical Engineering California Baptist University Riverside California USA.
University of Massachusetts Lowell · USCalifornia Baptist University · USKindred Hospital Rancho · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nose is the initial site of viral infection, replication, and transmission in the human body. Nasally inhaled vaccines may act as a promising alternative for COVID-19 management in addition to intramuscular vaccination. In this review, the latest developments of nasal sprays either as repurposed or antiviral formulations were presented. Nasal vaccines based on traditional medicines, such as grapefruit seed extract, algae-isolated carrageenan, and Yogurt-fermenting

Indexed as

ACE2COVID‐19 managementinhaled vaccinemucociliary clearancenasal sprayviral entry

Identifiers

PMID34977869
PMCPMC8706742
OpenAlexW4200349553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.