Evidence map›Paper›PMID 34977849›Full record

ArticleCell reports methods2021

Transcriptome signature of cell viability predicts drug response and drug interaction in

Vivek Srinivas, Rene A Ruiz, Min Pan, Selva Rupa Christinal Immanuel, Eliza J R Peterson, Nitin S Baliga

Open access · goldAbstract read
In one paragraph

Article in Cell reports methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Transcriptomic responses to antibiotic exposure inAntimicrobial agents and chemotherapy · 2024
    Article
  5. Review
  6. Review
  7. MadR mediates acyl CoA-dependent regulation of mycolic acid desaturation in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vivek SrinivasInstitute for Systems Biology, Seattle, WA, USA.
Rene A RuizInstitute for Systems Biology, Seattle, WA, USA.
Min PanInstitute for Systems Biology, Seattle, WA, USA.
Selva Rupa Christinal ImmanuelInstitute for Systems Biology, Seattle, WA, USA.
Eliza J R PetersonInstitute for Systems Biology, Seattle, WA, USA.
Nitin S BaligaInstitute for Systems Biology, Seattle, WA, USA.
Institute for Systems Biology · USLawrence Berkeley National Laboratory · US

Funding

Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1M
Technology CoreU19AI106761 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI SHERMAN, DAVID R, ZAK, DANIEL E · 2013 to 2017
$18.9M
Technology CoreU19AI135976 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADEREM, ALAN A · 2018 to 2022
$17.0M
A systems analysis of drug tolerance in Mycobacterium tuberculosisR01AI128215 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI Nitin S Baliga · 2017 to 2026
$8.8M
Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National StudyR01AI141953 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2019 to 2023
$5.7M
Gates Foundation INV-009322NIAID NIH HHS R01 AI128215NIAID NIH HHS R01 AI141953NIAID NIH HHS U19 AI100627NIAID NIH HHS U19 AI106761NIAID NIH HHS U19 AI135976
6 · The paper itself

Abstract

There is an urgent need for new drug regimens to rapidly cure tuberculosis. Here, we report the development of drug response assayer (DRonA) and "MLSynergy," algorithms to perform rapid drug response assays and predict response of

Indexed as

Mycobacterium tuberculosisCell SurvivalDrug CombinationsDrug InteractionsHumansTranscriptomeDrug Combinationscomputational modeldrug combinationsdrug-resistant tuberculosisdrug response predictiondrug synergymachine learningTB drug discoveryTB treatment regimenstuberculosis

Identifiers

PMID34977849
PMCPMC8688151
OpenAlexW4200283033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.