Evidence map›Paper›PMID 34977833›Full record

ArticleAmerican journal of preventive cardiology2022

Association of pepper intake with all-cause and specific cause mortality - A systematic review and meta-analysis.

Manpreet Kaur, Beni R Verma, Leon Zhou, Hassan Mehmood Lak, Simrat Kaur, Yasser M Sammour, Samir R Kapadia, Richard A Grimm, Brian P Griffin, Bo Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Lifestyle factors and cardiometabolic risk.Chinese medical journal · 2026
    Review
  2. Article
  3. Article
  4. Capsaicin: a spicy way in liver disease.Frontiers in pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manpreet KaurRobert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195.
Beni R VermaDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, 44195.
Leon ZhouDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, 44195.
Hassan Mehmood LakDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, 44195.
Simrat KaurDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, 44195.
Yasser M SammourDepartment of Internal Medicine, University of Missouri-Kansas City, MO, 64110.
Samir R KapadiaRobert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195.
Richard A GrimmRobert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195.
Brian P GriffinRobert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195.
Bo XuRobert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, 44195.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo conduct a comprehensive systematic review and meta-analysis to compare mortality and other clinical outcomes associated with chili pepper (CP) consumption versus no/rare consumption of CP.

methodsA comprehensive search was performed using Ovid, Cochrane, Medline, EMBASE, and Scopus from inception till January 16, 2020. Observational studies and randomized controlled trials were included, while pediatric/animal studies, letters/case reports, reviews, abstracts, and book chapters were excluded. All-cause mortality was studied as the primary outcome. Cardiovascular mortality, cancer-related deaths and cerebrovascular accidents were studied as secondary outcomes.

resultsFrom 4729 studies, four studies met the inclusion criteria. Random effects pooled analysis showed that all-cause mortality among CP consumers was lower, compared to rare/non-consumers, with a hazard ratio (HR) of 0.87 [95% CI: 0.85-0.90;

conclusionRegular CP consumption was associated with significantly lower all-cause, cardiovascular, and cancer-related mortalities. However, based on current literature, it is difficult to derive a standardized approach to guide the optimal mode and amount of CP consumption. This warrants well-designed prospective studies to further investigate the potential health benefits of CP consumption.

Indexed as

ACC, American College of CardiologyAll-cause mortalityCancer-related mortalityCardiovascular accidentsCardiovascular mortalityChili-pepperCP, chili pepperCVA, cerebrovascular accidentsDM, diabetes mellitusPICO, population, intervention, comparison, and outcomes

Identifiers

PMID34977833
PMCPMC8688560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.