Evidence map›Paper›PMID 34977830›Full record

ArticleThe Lancet. Microbe2021

Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study.

Mark S Pearson, Bemnet A Tedla, Gebeyaw G Mekonnen, Carla Proietti, Luke Becker, Rie Nakajima, Al Jasinskas, Denise L Doolan, Abena S Amoah, Stefanie Knopp and 20 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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  11. Trematode Genomics and Proteomics.Advances in experimental medicine and biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 13 institutions in 11 countries.

Mark S PearsonCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Bemnet A TedlaCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Gebeyaw G MekonnenCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Carla ProiettiCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Luke BeckerCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Rie NakajimaUniversity of California Irvine, Irvine, CA, USA.
Al JasinskasUniversity of California Irvine, Irvine, CA, USA.
Denise L DoolanCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Abena S AmoahDepartment of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
Stefanie KnoppSwiss Tropical and Public Health Institute, Basel, Switzerland.
David RollinsonWolfson Wellcome Biomedical Laboratories, Department of Life Sciences, Natural History Museum, London, UK.
Said M AliPublic Health Laboratory, Ivo de Carneri, Pemba, Tanzania.
Fatma KaboleNeglected Diseases Programme, Ministry of Health, Unguja, Tanzania.
Cornelis H HokkeDepartment of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
Akim A AdegnikaDepartment of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
Matt A FieldCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Govert van DamDepartment of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
Paul L A M CorstjensDepartment of Molecular Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Takafira MduluzaBiochemistry Department, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe.
Francisca MutapiDepartment of Molecular Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Claude OeuvrayMerck Global Health Institute, Eysins, Switzerland.
Beatrice GrecoMerck Global Health Institute, Eysins, Switzerland.
Sujittra ChaiyadetTropical Medicine Graduate Program, Academic Affairs, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Thewarach LahaDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Pengfei CaiQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Donald P McManusQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Maria Elena BottazziTexas Children's Hospital Center for Vaccine Development, Department of Pediatrics and National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.
Philip L FelgnerUniversity of California Irvine, Irvine, CA, USA.
Javier SotilloCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Alex LoukasCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Australian Institute of Tropical Health and Medicine · AULeiden University Medical Center · NLJames Cook University · AUUniversity of California, Irvine · USKhon Kaen University · THMerck Serono (Switzerland) · CHQIMR Berghofer Medical Research Institute · AUMinistry of Health and Social Welfare · TZNatural History Museum · GBPublic Health Laboratory Ivo de Carneri · TZTexas Children's Hospital · USUniversity of Basel · CHUniversity of Zimbabwe · ZW

Funding

Wellcome TrustWellcome Trust 108061/Z/15/Z
6 · The paper itself

Abstract

backgroundSensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the

methodsWe did a biomarker identification study, in which we constructed a proteome array containing 992 validated and predicted proteins from

findingsFrom array probing, in individuals who were infected, 208 antigens were the targets of significantly elevated IgG responses in serum and 45 antigens were the targets of significantly elevated IgG responses in urine. Of the five proteins that were validated by ELISA,

interpretationWe identified numerous biomarkers of urogenital schistosomiasis that could form the basis of novel antibody diagnostics for this disease. Two of these antigens,

fundingAustralian Trade and Investment Commission and Merck Global Health Institute.

Indexed as

Schistosomiasis haematobiaAnimalsAustraliaBiomarkersFemaleHumansImmunoglobulin GMaleProteomeSchistosoma haematobiumBiomarkersImmunoglobulin GProteome

Identifiers

PMID34977830
PMCPMC8683377
OpenAlexW3197249661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.