Evidence map›Paper›PMID 34977599›Full record

ArticleCurrent research in physiology2022

The role of M3 receptors in regulation of electrical activity deteriorates in the rat heart during ageing.

Svetlana V Tapilina, Alexandra D Ivanova, Tatiana S Filatova, Pavel A Galenko-Yaroshevsky, Denis V Abramochkin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Role of Muscarinic Acetylcholine Receptor MInternational journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Svetlana V TapilinaDepartment of Human and Animal Physiology, Moscow State University, Leninskiye Gory 1, 12, Moscow, Russia.
Alexandra D IvanovaDepartment of Human and Animal Physiology, Moscow State University, Leninskiye Gory 1, 12, Moscow, Russia.
Tatiana S FilatovaDepartment of Human and Animal Physiology, Moscow State University, Leninskiye Gory 1, 12, Moscow, Russia.
Pavel A Galenko-YaroshevskyDepartment of Pharmacology, Kuban' State Medical University, Sedina Str. 4, Krasnodar, Russia.
Denis V AbramochkinDepartment of Human and Animal Physiology, Moscow State University, Leninskiye Gory 1, 12, Moscow, Russia.
Lomonosov Moscow State University · RUKuban State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is a complex process which affects all systems of the organism and therefore changes the environment where the heart is working. In this study we demonstrate the ageing-related changes in the mechanisms of parasympathetic regulation of mammalian heart. Electrophysiological effects produced by selective activation of M3-cholinoreceptors were compared in isolated cardiac preparations from young adult (4 months), adult (1 year) and ageing (2 years) rats using sharp glass microelectrode technique. M3-receptors were activated with muscarinic agonist pilocarpine (10

Indexed as

Action potentialAgeingCalcium currentHeartM3 receptorsMuscarinic receptorsRat

Identifiers

PMID34977599
PMCPMC8685909
OpenAlexW4200078499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.