Evidence map›Paper›PMID 34977580›Full record

ArticleRSC chemical biology2021

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity.

Nicholas J Cundy, Roseanna K Hare, Tina Tang, Andrew G Leach, Thomas A Jowitt, Omar Qureshi, John Gordon, Nicholas M Barnes, Catherine A Brady, Emma L Raven and 2 more

Open access · goldAbstract read
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Deciphering Tryptophan Oxygenation: Key Modulators of 2-Oxindole Formation in MarE.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Nicholas J CundySchool of Chemistry, University of Birmingham Edgbaston Birmingham B15 2TT UK r.s.grainger@bham.ac.uk.ORCID https://orcid.org/0000-0001-6783-5422
Roseanna K HareDivision of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester Manchester M13 9PL UK.
Tina TangCelentyx Ltd, Birmingham Research Park 97 Vincent Drive Birmingham B15 2SQ UK.
Andrew G LeachDivision of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester Manchester M13 9PL UK sam.butterworth@manchester.ac.uk.ORCID https://orcid.org/0000-0003-1325-8273
Thomas A JowittWellcome Trust Centre for Cell Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester Manchester M13 9PL UK.
Omar QureshiCelentyx Ltd, Birmingham Research Park 97 Vincent Drive Birmingham B15 2SQ UK.
John GordonCelentyx Ltd, Birmingham Research Park 97 Vincent Drive Birmingham B15 2SQ UK.
Nicholas M BarnesCelentyx Ltd, Birmingham Research Park 97 Vincent Drive Birmingham B15 2SQ UK.
Catherine A BradyCelentyx Ltd, Birmingham Research Park 97 Vincent Drive Birmingham B15 2SQ UK.
Emma L RavenSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK.
Richard S GraingerSchool of Chemistry, University of Birmingham Edgbaston Birmingham B15 2TT UK r.s.grainger@bham.ac.uk.ORCID https://orcid.org/0000-0003-0611-4386
Sam ButterworthDivision of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester Manchester M13 9PL UK sam.butterworth@manchester.ac.uk.
Birmingham Research Park · GBUniversity of Manchester · GBUniversity of Birmingham · GBUniversity of Bristol · GBWellcome Centre for Cell-Matrix Research · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The metabolism of l-tryptophan to

Identifiers

PMID34977580
PMCPMC8637876
OpenAlexW3200282933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.