Evidence map›Paper›PMID 34977574›Full record

ArticleRSC chemical biology2021

A silicon-rhodamine chemical-genetic hybrid for far red voltage imaging from defined neurons in brain slice.

Gloria Ortiz, Pei Liu, Parker E Deal, Ashley K Nensel, Kayli N Martinez, Kiarash Shamardani, Hillel Adesnik, Evan W Miller

Abstract read
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Tension TRAAKer: a chemigenetic fluorescent membrane tension reporter.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Voltage Imaging inFrontiers in neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gloria OrtizDepartment of Chemistry, University of California Berkeley California 94720-1460 USA evanwmiller@berkeley.edu.
Pei LiuDepartment of Chemistry, University of California Berkeley California 94720-1460 USA evanwmiller@berkeley.edu.
Parker E DealDepartment of Chemistry, University of California Berkeley California 94720-1460 USA evanwmiller@berkeley.edu.ORCID https://orcid.org/0000-0002-9960-3957
Ashley K NenselDepartment of Chemistry, University of California Berkeley California 94720-1460 USA evanwmiller@berkeley.edu.
Kayli N MartinezDepartment of Chemistry, University of California Berkeley California 94720-1460 USA evanwmiller@berkeley.edu.
Kiarash ShamardaniDepartment of Molecular & Cell Biology, University of California Berkeley California 94720-1460 USA.ORCID https://orcid.org/0000-0002-2548-705X
Hillel AdesnikDepartment of Molecular & Cell Biology, University of California Berkeley California 94720-1460 USA.
Evan W MillerDepartment of Chemistry, University of California Berkeley California 94720-1460 USA evanwmiller@berkeley.edu.ORCID https://orcid.org/0000-0002-6556-7679

Funding

Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage SensorsR01NS098088 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Evan Walker Miller · 2017 to 2026
$4.4M
NINDS NIH HHS R01 NS098088
6 · The paper itself

Abstract

We describe the design, synthesis, and application of voltage-sensitive silicon rhodamines. Based on the Berkeley Red Sensor of Transmembrane potential, or BeRST, scaffold, the new dyes possess an isomeric molecular wire for improved alignment in the plasma membrane and 2' carboxylic acids for ready functionalization. The new isoBeRST dyes have a voltage sensitivity of 24% Δ

Identifiers

PMID34977574
PMCPMC8637932

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.