Evidence map›Paper›PMID 34977556›Full record

ArticleInternational journal of pharmaceutics: X2021

Influence of probiotic bacteria on gut microbiota composition and gut wall function in an

Jonas Ghyselinck, Lynn Verstrepen, Frédéric Moens, Pieter Van Den Abbeele, Arnout Bruggeman, Jawal Said, Barry Smith, Lynne Ann Barker, Caroline Jordan, Valentina Leta and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Nutrients · 2025
    Pooled it
  2. Pooled it
  3. International journal of molecular sciences · 2024
    Pooled it
  4. Pooled it
  5. Trial
  6. Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Gut Microbiome as a Source of Probiotic Drugs for Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  9. Marine drugs · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Psychobiotic Properties ofInternational journal of molecular sciences · 2024
    Review
  14. Review
  15. Viability and probiotic activity ofFood science and biotechnology · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Jonas GhyselinckProDigest BV, Technologiepark 94, 9052 Ghent, Belgium.
Lynn VerstrepenProDigest BV, Technologiepark 94, 9052 Ghent, Belgium.
Frédéric MoensProDigest BV, Technologiepark 94, 9052 Ghent, Belgium.
Pieter Van Den AbbeeleProDigest BV, Technologiepark 94, 9052 Ghent, Belgium.
Arnout BruggemanDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Jawal SaidUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Barry SmithSymprove Ltd, Sandy Farm, The Sands, Farnham, Surrey GU10 1PX, UK.
Lynne Ann BarkerCentre for Behavioural Science and Applied Psychology, Cognition and Neuroscience Group, Sheffield Hallam University, Collegiate Crescent Campus, Sheffield S10 2BQ, UK.
Caroline JordanCentre for Behavioural Science and Applied Psychology, Cognition and Neuroscience Group, Sheffield Hallam University, Collegiate Crescent Campus, Sheffield S10 2BQ, UK.
Valentina LetaParkinson's Foundation Centre of Excellence, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
K Ray ChaudhuriParkinson's Foundation Centre of Excellence, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
Abdul W BasitUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Simon GaisfordUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
ProDigest (Belgium) · BEUniversity College London · GBSheffield Hallam University · GBGhent University Hospital · BEKing's College Hospital NHS Foundation Trust · GBKing's College London · GBSands · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report here the potential role of a 4-strain probiotic suspension for use with patients with Parkinson's disease (PD). Stool samples from a group of three patients with diagnosed PD were used to create microbiotas in an

Indexed as

ButyrateEpithelial gut wall integrityGastrointestinal microbiomeLactobacillusParkinson's diseaseProbiotics

Identifiers

PMID34977556
PMCPMC8683682
OpenAlexW3179103051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.