Evidence map›Paper›PMID 34977555›Full record

ArticleInternational journal of pharmaceutics: X2021

In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters.

Sawittree Sahakijpijarn, Chaeho Moon, Zachary N Warnken, Esther Y Maier, Jennie E DeVore, Dale J Christensen, John J Koleng, Robert O Williams

Open access · goldAbstract read
In one paragraph

Article in International journal of pharmaceutics: X, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

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  18. Scoping insight on antiviral drugs against COVID-19.Arabian journal of chemistry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sawittree SahakijpijarnDivision of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
Chaeho MoonDivision of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
Zachary N WarnkenDivision of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
Esther Y MaierDrug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, Austin, TX 78723, USA.
Jennie E DeVoreDrug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, Austin, TX 78723, USA.
Dale J ChristensenTFF Pharmaceuticals, Inc., Austin, TX 78746, USA.
John J KolengTFF Pharmaceuticals, Inc., Austin, TX 78746, USA.
Robert O WilliamsDivision of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
The University of Texas at Austin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 levels higher than the reported EC

Indexed as

COVID-19Dry powder for inhalationPharmacokineticsRemdesivirSARS-CoV-2Thin film freezing

Identifiers

PMID34977555
PMCPMC8683664
OpenAlexW3134794611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.