ArticleEClinicalMedicine2022
Maternal mortality among women with sickle cell disease in Jamaica over two decades (1998-2017).
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025Review
- Characterizing pregnancy outcomes in a humanized mouse model of sickle cell disease.British journal of haematology · 2025Article
- New WHO recommendations on the management of sickle-cell disease in pregnancy.Pregnancy (Hoboken, N.J.) · 2025Article
- Interpregnancy management for women with sickle cell disease: A systematic review.Pregnancy (Hoboken, N.J.) · 2025Review
- Maternal and perinatal outcomes of sickle cell disease in pregnancy: A nationwide study in France.British journal of haematology · 2025Article
- Burden of hemoglobinopathies and hemolytic anemias in the World Health Organization African region, 2000-2021: Findings from the Global Burden of Disease 2021 study.PLOS global public health · 2025Article
- Sickle cell disease and infertility risks: implications for counseling and care of affected girls and women.Expert review of hematology · 2024Review
- Case Report: Obstetric and COVID-19-Related Morbidity and Mortality in Three Patients with Sickle Hemoglobinopathy.The American journal of tropical medicine and hygiene · 2024Article
- Adverse pregnancy, fetal and neonatal outcomes in women with sickle cell disease in a Middle Eastern country.Women's health (London, England)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSickle cell disease (SCD) affects 2.8% of Jamaican antenatal women. Between 1998-2007 their maternal mortality ratio was 7-11 times higher than women without these disorders. We aim to determine if outcomes improved between 2008 and 17 amid declining fertility and changes in referral obstetric care.
methodsMaternal deaths in Jamaica's maternal mortality surveillance database (assembled since 1998) with SCD reported as underlying or associated cause of death were compared to those without known SCD, over two decades from 1998 to 2017. Social, demographic and health service variables were analysed using SPSS and EpiInfo Open.
findingsOver the two decades from 1998 to 2017, 806 (74%) of the 1082 pregnancy-associated deaths documented by the Jamaican Ministry of Health and Wellness were maternal deaths. The maternal mortality ratio (MMR) did not statistically change over the two periods for women with (
interpretationMMRs were unchanged over two decades for Jamaicans with SCD. The high contribution to maternal mortality by women with SCD may explain some of the persistently higher mortality experience of women in the African diaspora. Multi-disciplinary evidence-based strategies need to be developed and tested which improve survival for women with SCD who want to have children.
fundingNo external funding was provided.
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