Evidence map›Paper›PMID 34977436›Full record

ArticleInfectious Disease Modelling2022

Optimal control analysis of hepatocytic-erythrocytic dynamics of

Titus Okello Orwa, Rachel Waema Mbogo, Livingstone Serwadda Luboobi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious Disease Modelling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Titus Okello OrwaInstitute of Mathematical Sciences, Strathmore University, P.O Box 59 857-00 200, Nairobi, Kenya.
Rachel Waema MbogoInstitute of Mathematical Sciences, Strathmore University, P.O Box 59 857-00 200, Nairobi, Kenya.
Livingstone Serwadda LuboobiInstitute of Mathematical Sciences, Strathmore University, P.O Box 59 857-00 200, Nairobi, Kenya.
Strathmore University · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents an in-host malaria model subject to anti-malarial drug treatment and malaria vaccine antigens combinations. Pontryagin's Maximum Principle is applied to establish optimal control strategies against infected erythrocytes, infected hepatocytes and malaria parasites. Results from numerical simulation reveal that a combination of pre-erythrocytic vaccine antigen, blood schizontocide and gametocytocide drugs would offer the best strategy to eradicate clinical

Indexed as

Blood schizontocideGametocytocideMalaria vaccinesOptimal controlP. falciparum malariaPontryagin's Maximum Principle

Identifiers

PMID34977436
PMCPMC8686038
OpenAlexW4200355394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.