Evidence map›Paper›PMID 34977408›Full record

ArticleHeliyon2021

Increased bone resorption by long-term cigarette smoke exposure in animal model.

Jader Joel Machado Junqueira, Juliana Dias Lourenço, Kaique Rodrigues da Silva, Vanda Jorgetti, Rodolfo P Vieira, Amanda Aparecida de Araujo, Kátia De Angelis, Aristides Tadeu Correia, Luan Henrique Vasconcelos Alves, Iolanda de Fátima Lopes Calvo Tibério and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jader Joel Machado JunqueiraDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Juliana Dias LourençoDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Kaique Rodrigues da SilvaDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Vanda JorgettiDepartment of Medicine, Laboratory of Renal Physiopathology (LIM-16), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Rodolfo P VieiraPost-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
Amanda Aparecida de AraujoExercise Physiology Laboratory, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
Kátia De AngelisExercise Physiology Laboratory, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
Aristides Tadeu CorreiaDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Luan Henrique Vasconcelos AlvesDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Iolanda de Fátima Lopes Calvo TibérioDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Alexandre Póvoa BarbosaDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Fernanda Degobbi Tenorio Quirino Dos Santos LopesDepartment of Medicine, Laboratory of Experimental Therapeutics (LIM-20), School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRUniversidade Brasil · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClinical and experimental studies have been attesting the deleterious effects of smoking mainly due to the stimulation of osteoclastogenesis and inhibition of osteoblastogenesis. However the physiological mechanisms that can explain these changes are not fully understood.

aimsTo evaluate the trabecular bone resorption effect caused by long-term exposure to cigarette smoke and the action of cytokines and reactive oxygen species involved in this process.

methodsSixty young adult C57BL/6 mice were allocated to two groups: control, 30 animals exposed to filtered air for 1, 3 and 6 months; and smoke, 30 animals exposed to cigarette smoke for 1, 3 and 6 months. Femoral and tibial extraction was performed to evaluate the bone mineral matrix, bone cytokines (Receptor activator of nuclear factor-kappa B ligand - RANKL and Osteoprotegerin - OPG) and oxidative stress markers (Thiobarbituric acid reactive substances - Tbars).

resultsExposure to cigarette smoke (CS) generated changes in bone structural parameters in the 6th month of follow-up, demonstrating an evident bone loss; reduction in OPG/RANKL ratio from the 3rd month on and increase in Tbars in the first month, both closely related to the increase in osteoclastogenic activity and bone resorption.

conclusionThese findings reinforce the importance of CS-induced oxidative stress in bone compromising the bone cellular activities with a consequent impairment in bone turn over and changes in bone structure.

Indexed as

Bone matrixBone remodelingOxidative stressSmoking

Identifiers

PMID34977408
PMCPMC8686037
OpenAlexW4225603602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.