Evidence map›Paper›PMID 34977329›Full record

ArticleInternational journal of cardiology. Heart & vasculature2022

Relationship between lung injury extent and phenotype manifested in non-contrast CT and cardiac injury during acute stage of COVID-19.

Aaron So, Zehong Yang, Liang Li, Wang Li, Cheng Pan, Prushoth Vivekanantha, Hye Won Yun, Xin Yue Xie, Chun-Ho Yun, Wei-Ming Huang and 5 more

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Article in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Aaron SoImaging Program, Lawson Health Research Institute, London, Ontario, Canada.
Zehong YangDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Liang LiDepartment of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Wang LiDepartment of Infection Prevention and Control Office, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Cheng PanCritical Care, London Health Sciences Centre, London, Ontario, Canada.
Prushoth VivekananthaDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Hye Won YunDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Xin Yue XieDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Chun-Ho YunDepartment of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.
Wei-Ming HuangDepartment of Radiology, Mackay Memorial Hospital, Taipei, Taiwan.
Chung-Lieh HungDepartment of Cardiology, Mackay Memorial Hospital, Taipei, Taiwan.
Ming GaoDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xiang ZhangDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Yunfei ZhaDepartment of Infection Prevention and Control Office, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Jun ShenDepartment of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study evaluated the diagnostic values of the extent of lung injury manifested in non-contrast enhanced CT (NCCT) images, the inflammatory and immunological biomarkers C-reactive protein (CRP) and lymphocyte for detecting acute cardiac injury (ACI) in patients with COVID-19. The correlations between the NCCT-derived parameters and arterial blood oxygen level were also investigated.

methodsNCCT lung images and blood tests were obtained in 143 patients with COVID-19 in approximately two weeks after symptom onset, and arterial blood gas measurement was also acquired in 113 (79%) patients. The diagnostic values of normal, moderately and severely abnormal lung parenchyma volume relative to the whole lungs (RVNP, RVMAP, RVSAP, respectively) measured from NCCT images for detecting the heart injury confirmed with high-sensitivity troponin I assay was determined.

resultsRVNP, RVMAP and RVSAP exhibited similar accuracy for detecting ACI in COVID-19 patients. RVNP was significantly lower while both RVMAP and RVSAP were significantly higher in the patients with ACI. All of the NCCT-derived parameters exhibited poor linear and non-linear correlations with P

conclusionThe NCCT-delineated normal and abnormal lung parenchmyma tissues were statistically significant predictors of ACI in patients with COVID-19, but both exhibited poor correlations with the arterial blood oxygen level. The incremental diagnostic values of lymphocyte and CRP suggested viral infection and inflammation were closely related to the heart injury during the acute stage of COVID-19.

Indexed as

Acute cardiac injuryCOVID-19InflammationNon-contrast computed tomography (NCCT)SARS-CoV-2

Identifiers

PMID34977329
PMCPMC8709798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.