ArticleBone reports2022
Leptin to adiponectin ratio in puberty is associated with bone mineral density in 18-year-old males.
Article in Bone reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Adipocytokine imbalance and bone mineral properties in Hispanic youth.Pediatric research · 2026Article
- Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Relationships between Body Weight Status and Serum Levels of Adipokine, Myokine and Bone Metabolism Parameters in Healthy Normal Weight and Thin Children.Journal of clinical medicine · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInconsistent associations of leptin and adiponectin with bone mineral characteristics in puberty and adolescence have been reported. We aimed to examine the associations between leptin to adiponectin ratio (LAR) in puberty and bone mineral characteristics at the age of 18 years in healthy males. MATERIALS AND
methods88 white Caucasian boys were investigated at T1 (mean age 12.1 years), T2 (14.0 years) and T3 (18.0 years). Serum leptin and adiponectin were measured and LAR was calculated at T1, T2 and T3, bone mineral density (BMD) and bone mineral apparent density (BMAD) for total body and lumbar spine (LS) at T1 and T3. Spearman correlation coefficient and partial correlation analyses were used to describe the associations between mean pubertal LAR and BMD at T3.
resultsMean pubertal LAR was negatively correlated with both LS BMD (r = -0.23; P < 0.05) and LS BMAD at T3 (r = -0.33; P < 0.05). These associations remained significant also in partial correlation analysis after controlling for total body fat percentage, total testosterone, HOMA-IR and physical activity at T1 (r = -0.31; P < 0.05 and r = -0.41; P < 0.05 respectively).
conclusionLAR in puberty is negatively associated with lumbar spine BMD and lumbar spine BMAD at the age of 18 years.
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