Evidence map›Paper›PMID 34977273›Full record

ArticleMolecular therapy. Methods & clinical development2022

RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome.

Altar M Munis, Benjamin Wright, Frederic Jackson, Helen Lockstone, Stephen C Hyde, Catherine M Green, Deborah R Gill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The evolution ofEuropean respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  3. Article
  4. Progress in Respiratory Gene Therapy.Human gene therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Altar M MunisGene Medicine Group, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Benjamin WrightBioinformatics and Statistical Genetics Core, Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Frederic JacksonClinical BioManufacturing Facility, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7JT, UK.
Helen LockstoneBioinformatics and Statistical Genetics Core, Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Stephen C HydeGene Medicine Group, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Catherine M GreenClinical BioManufacturing Facility, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7JT, UK.
Deborah R GillGene Medicine Group, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
University of Oxford · GBCentre for Human Genetics · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Understanding pulmonary diseases requires robust culture models that are reproducible, sustainable in long-term culture, physiologically relevant, and suitable for assessment of therapeutic interventions. Primary human lung cells are physiologically relevant but cannot be cultured

Indexed as

ALIATIATIIH441lungparenchymaRNA-seqSALISPBsurfactant

Identifiers

PMID34977273
PMCPMC8688965
OpenAlexW3215534519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.