Evidence map›Paper›PMID 34977210›Full record

ArticleFrontiers in veterinary science2021

Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.

Zhaoyan Lin, Zixiang Lin, Ying Zhao, Nan Cheng, Di Zhang, Jiahao Lin, Hong Zhang, Degui Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhaoyan LinDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zixiang LinDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Ying ZhaoDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Nan ChengDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Di ZhangDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jiahao LinDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Hong ZhangCollege of Animal Science and Technology, Hainan University, Haikou, China.
Degui LinDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, China.
China Agricultural University · CNHainan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, which has been found as a great anti-tumor agent in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we demonstrated that a combination of AF and ICG-001 could synergistically suppress the proliferation of CBC

Indexed as

auranofinCBCICG-001mitochondrial pathwayROS

Identifiers

PMID34977210
PMCPMC8714754
OpenAlexW4200064268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.