Evidence map›Paper›PMID 34977113›Full record

ReviewFrontiers in nutrition2021

CRISPR-Cas-Led Revolution in Diagnosis and Management of Emerging Plant Viruses: New Avenues Toward Food and Nutritional Security.

Susheel Kumar Sharma, Om Prakash Gupta, Neeta Pathaw, Devender Sharma, Albert Maibam, Parul Sharma, Jyotsana Sanasam, Suhas Gorakh Karkute, Sandeep Kumar, Bijoya Bhattacharjee

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

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  8. Rapid and accurate detection ofFrontiers in plant science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Susheel Kumar SharmaICAR Research Complex for NEH Region, Manipur Centre, Imphal, India.
Om Prakash GuptaDivision of Quality & Basic Science, ICAR-Indian Institute of Wheat and Barley Research, Karnal, India.
Neeta PathawICAR Research Complex for NEH Region, Manipur Centre, Imphal, India.
Devender SharmaCrop Improvement Division, ICAR-Vivekananda Parvatiya Krishi Anusandhan Sansthan, Almora, India.
Albert MaibamICAR Research Complex for NEH Region, Manipur Centre, Imphal, India.
Parul SharmaDepartment of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, India.
Jyotsana SanasamICAR Research Complex for NEH Region, Manipur Centre, Imphal, India.
Suhas Gorakh KarkuteDivision of Crop Improvement, ICAR-Indian Institute of Vegetable Research, Varanasi, India.
Sandeep KumarDepartment of Plant Pathology, Odisha University of Agriculture & Technology, Bhubaneswar, India.
Bijoya BhattacharjeeICAR Research Complex for NEH Region, Umiam, India.
ICAR Research Complex for NEH Region · INIndian Institute of Vegetable Research · INIndian Institute of Wheat and Barley Research · INOdisha University of Agriculture and Technology · INPunjab Agricultural University · INVivekananda Parvatiya Krishi Anusandhan Sansthan · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant viruses pose a serious threat to agricultural production systems worldwide. The world's population is expected to reach the 10-billion mark by 2057. Under the scenario of declining cultivable land and challenges posed by rapidly emerging and re-emerging plant pathogens, conventional strategies could not accomplish the target of keeping pace with increasing global food demand. Gene-editing techniques have recently come up as promising options to enable precise changes in genomes with greater efficiency to achieve the target of higher crop productivity. Of genome engineering tools, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) proteins have gained much popularity, owing to their simplicity, reproducibility, and applicability in a wide range of species. Also, the application of different Cas proteins, such as Cas12a, Cas13a, and Cas9 nucleases, has enabled the development of more robust strategies for the engineering of antiviral mechanisms in many plant species. Recent studies have revealed the use of various CRISPR-Cas systems to either directly target a viral gene or modify a host genome to develop viral resistance in plants. This review provides a comprehensive record of the use of the CRISPR-Cas system in the development of antiviral resistance in plants and discusses its applications in the overall enhancement of productivity and nutritional landscape of cultivated plant species. Furthermore, the utility of this technique for the detection of various plant viruses could enable affordable and precise in-field or on-site detection. The futuristic potential of CRISPR-Cas technologies and possible challenges with their use and application are highlighted. Finally, the future of CRISPR-Cas in sustainable management of viral diseases, and its practical utility and regulatory guidelines in different parts of the globe are discussed systematically.

Indexed as

CRISPR-CasCRISPR regulatory frameworkdiagnosticsfood and nutritional securitygenome editingmanagementviral resistance

Identifiers

PMID34977113
PMCPMC8716883
OpenAlexW4200162161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.