Evidence map›Paper›PMID 34977031›Full record

ArticleFrontiers in cell and developmental biology2021

Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (

Sanam Shafaattalab, Alison Y Li, Marvin G Gunawan, BaRun Kim, Farah Jayousi, Yasaman Maaref, Zhen Song, James N Weiss, R John Solaro, Zhilin Qu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
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  12. A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
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  13. Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sanam ShafaattalabBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Alison Y LiBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Marvin G GunawanBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
BaRun KimCellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Farah JayousiBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Yasaman MaarefBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Zhen SongUCLA Cardiac Computation Lab, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
James N WeissUCLA Cardiac Computation Lab, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
R John SolaroDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, United States.
Zhilin QuUCLA Cardiac Computation Lab, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Glen F TibbitsBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
BC Children's Hospital · CASimon Fraser University · CAUniversity of California, Los Angeles · USUniversity of Illinois Chicago · US

Funding

Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
A population-based in silico platform for arrhythmia predictionR01HL134709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R01 HL134709
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disease and often results in cardiac remodeling and an increased incidence of sudden cardiac arrest (SCA) and death, especially in youth and young adults. Among thousands of different variants found in HCM patients, variants of

Indexed as

cardiomyocyte calciumhuman iPSC-derived cardiomyocyte (hiPSC-CM)hypertrophic cardiomyopathyoptical mapping of calcium and action potentialstroponin T

Identifiers

PMID34977031
PMCPMC8718794
OpenAlexW4200253809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.