Evidence map›Paper›PMID 34977026›Full record

ArticleFrontiers in cell and developmental biology2021

PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7.

Zhengnan Huang, Jiakuan Liu, Jiale Yang, Yilin Yan, Chenkai Yang, Xiao He, Ruimin Huang, Mingyue Tan, Denglong Wu, Jun Yan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

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  6. EZH2 promotes malignant biological behavior in esophageal squamous cell carcinoma via EMT.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Zhengnan HuangDepartment of Urology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Jiakuan LiuDepartment of Laboratory Animal Science, Fudan University, Shanghai, China.
Jiale YangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yilin YanDepartment of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Chenkai YangDepartment of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiao HeShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Ruimin HuangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Mingyue TanDepartment of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Denglong WuDepartment of Urology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Jun YanDepartment of Laboratory Animal Science, Fudan University, Shanghai, China.
Bing ShenDepartment of Urology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Shanghai First People's Hospital · CNFudan University · CNTongji University · CNNanjing University of Chinese Medicine · CNShanghai Institute of Materia Medica · CNShuguang Hospital · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary bladder cancer (UBC) is a common malignant tumor with high incidence. Advances in the diagnosis and treatment of this disease demand the identification of novel therapeutic targets. Multiple studies demonstrated that PDE4B level was upregulated in malignancies and high PDE4B expression was correlated with poor outcomes. Herein, we identified that PDE4B was a potential therapeutic target in UBC. We confirmed that PDE4B expression was correlated with aggressive clinicopathological characteristics and unfavorable prognosis. Functional studies demonstrated that ectopic expression of PDE4B promoted UBC cells proliferation, migration and invasion, whereas PDE4B depletion suppressed cancer cell aggressiveness. We also identified CBX7 as a regulator of PDE4B to suppress the expression of PDE4B at the transcription level in a PRC1-dependent manner. Moreover, our results indicated that PDE4B induced epithelial-to-mesenchymal transition (EMT) in UBC cells

Indexed as

chromobox protein homolog 7epithelial-to-mesenchymal transitionphosphodiesterase 4Burinary bladder cancerβ-catenin

Identifiers

PMID34977026
PMCPMC8716816
OpenAlexW4200342910

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.