Evidence map›Paper›PMID 34977019›Full record

ReviewFrontiers in cell and developmental biology2021

Regeneration in Echinoderms: Molecular Advancements.

Joshua G Medina-Feliciano, José E García-Arrarás

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Sea CucumberResearch square · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumberComputational and structural biotechnology journal · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Ethical Considerations for Echinoderms: New Initiatives in Welfare.Animals : an open access journal from MDPI · 2023
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua G Medina-FelicianoUniversity of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.
José E García-ArrarásUniversity of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.

Funding

Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
Roadmap for Intestinal RegenerationR15GM124595 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI JOSE E GARCIA-ARRARAS · 2017 to 2026
$1.7M
Balancing degeneration and regeneration in the echinoderm nervous systemR21AG057974 · NIA · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI GARCIA-ARRARAS, JOSE E · 2017 to 2019
$646k
NIA NIH HHS R21 AG057974NIGMS NIH HHS R15 GM124595NIGMS NIH HHS R25 GM061151
6 · The paper itself

Abstract

Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates thought to be involved in tissue and organ regeneration have been identified. Several of these studies have been done in echinoderms, an animal group that forms part of the deuterostomes along with vertebrates. Echinoderms, with their outstanding regenerative abilities, can provide important insights into the molecular basis of regeneration. Here we review the available data to determine the genes and signaling pathways that have been proposed to be involved in regenerative processes. Our analyses provide a curated list of genes and gene signaling pathways and match them with the different cellular processes of the regenerative response. In this way, the molecular basis of echinoderm regenerative potential is revealed, and is available for comparisons with other animal taxa.

Indexed as

dedifferentiationechinodermgene functionregenerationsignaling pathwaystranscriptome analyses

Identifiers

PMID34977019
PMCPMC8718600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.