ReviewFrontiers in pediatrics2021
Recent Progress in Lymphangioma.
Review in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Orbital lymphangioma mimicking cellulitis: Diagnostic contribution of MRI and successful management with bleomycin sclerotherapy.Radiology case reports · 2026Article
- Mediastinal Lymphangioma of the Adult: Case Report and Literature Review.Clinics and practice · 2026Article
- Idiopathic anterior mediastinal lymphangioma in a young adult: a rare case report and review of management.International journal of surgery case reports · 2026Article
- Uncommon Presentation of a Macrocystic Lymphatic Malformation in a Seven-Year-Old Boy: A Case Report.Cureus · 2026Article
- Article
- Diagnosis of a Liver Lymphangioma Using Contrast-Enhanced Ultrasonography (CEUS): Single Case Report.Reports (MDPI) · 2026Article
- Large Intrapericardial Cystic Lymphangioma: Encircling the Right Coronary Artery.CASE (Philadelphia, Pa.) · 2026Article
- Mesenteric Hemolymphangioma: A Case Report and Literature Review.The American journal of case reports · 2026Review
- Pediatric scrotal lymphatic malformation: a 15-case series and a proposed diagnostic and management algorithm.Frontiers in pediatrics · 2026Article
- An unusual cause of ileal volvulus, a giant mesenteric cystic lymphangioma.Radiology case reports · 2025Article
- Imaging and Clinical Features of Primary Thoracic LymphangiomaCurrent medical imaging · 2025Article
- Cystic Lymphangioma in the Talus Bone: A Case Report.International medical case reports journal · 2025Article
- Article
- A multi-step approach to overcome challenges in the management of head and neck lymphatic malformations, and response to treatment.Orphanet journal of rare diseases · 2024Article
- Gallbladder fossa lymphangioma encasing the common bile duct: a case report and review of the literature.Annals of medicine and surgery (2012) · 2024Article
- Generalized cystic lymphangiomatosis incidentally diagnosed in an asymptomatic adult: Imaging findings of a very rare case.Radiology case reports · 2024Article
- Sclerotherapy in orbital lymphangioma: A case report.Radiology case reports · 2023Article
- Case report and literature review: Giant retroperitoneal cystic lymphangioma.Frontiers in surgery · 2023Article
- Case report: Generalized lymphatic anomaly of multiple abdominal organs in a young dog.Frontiers in veterinary science · 2023Article
- Osteopathy in Complex Lymphatic Anomalies.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphangioma is a common type of congenital vascular disease in children with a broad spectrum of clinical manifestations. The current classification of lymphangioma by International Society for the Study of Vascular Anomalies is largely based on the clinical manifestations and complications and is not sufficient for selection of therapeutic strategies and prognosis prediction. The clinical management and outcome of lymphangioma largely depend on the clinical classification and the location of the disease, ranging from spontaneous regression with no treatment to severe sequelae even with comprehensive treatment. Recently, rapid progression has been made toward elucidating the molecular pathology of lymphangioma and the development of treatments. Several signaling pathways have been revealed to be involved in the progression and development of lymphangioma, and specific inhibitors targeting these pathways have been investigated for clinical applications and clinical trials. Some drugs already currently in clinical use for other diseases were found to be effective for lymphangioma, although the mechanisms underlying the anti-tumor effects remain unclear. Molecular classification based on molecular pathology and investigation of the molecular mechanisms of current clinical drugs is the next step toward developing more effective individualized treatment of children with lymphangioma with reduced side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.