Evidence map›Paper›PMID 34976764›Full record

ArticleTranslational pediatrics2021

Characteristics and outcomes of glomerulonephritis with membranoproliferative pattern in children.

Linan Xu, Fengfang Wei, Jiayan Feng, Jiaojiao Liu, Jialu Liu, Xiaoshan Tang, Xiaoyan Fang, Jing Chen, Yihui Zhai, Haimei Liu and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Childhood Ayme-Gripp syndrome: A case report.The Journal of international medical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Linan Xu *Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Fengfang Wei *Affiliated Hospital of Putian University, Fujian, China.
Jiayan FengDepartment of Pathology, Children's Hospital of Fudan University, Shanghai, China.
Jiaojiao LiuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jialu LiuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaoshan TangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaoyan FangDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jing ChenDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yihui ZhaiDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Haimei LiuDepartment of Rheumatology, Children's Hospital of Fudan University, Shanghai, China.
Li SunDepartment of Rheumatology, Children's Hospital of Fudan University, Shanghai, China.
Yanyan QianClinical Genetic Center, Children's Hospital of Fudan University, Shanghai, China.
Bingbing WuClinical Genetic Center, Children's Hospital of Fudan University, Shanghai, China.
Huijun WangClinical Genetic Center, Children's Hospital of Fudan University, Shanghai, China.
Qian ShenDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jia RaoDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Hong XuDepartment of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMembranoproliferative glomerulonephritis (MPGN) is a rare histopathologic pattern of glomerular injury with limited studies in pediatric patients. Characteristics and outcomes of children with MPGN have also remained to be further explored.

methodsWe retrospectively reviewed the clinicopathological features, genetic findings, treatments and outcomes in 17 pediatric patients pathologically diagnosed with MPGN from 2007 to 2020 in the Children's National Medical Center in China.

resultsMedian age at disease onset was 9.9 years (IQR, 5.6-11.9 years). Most of the patients (12/17) had nephrotic range of proteinuria, and nephritic-nephrotic syndrome was the most common clinical presentation (35.2%). Secondary causes were identified in eight patients including hepatitis B virus (HBV) infection (n=4), methylmalonic acidemia (MMA, n=2), rheumatoid arthritis (RA, n=1) and Aymé-Gripp Syndrome (n=1). The nine patients with primary MPGN were further identified as immune-complex mediated MPGN (n=8), and unclassifiable MPGN (U-MGPN, n=1). Genetic analyses identified pathogenic variants of

conclusionsChildren with MPGN pattern present heterogenous clinical features. Genetic detection helps to explore underlying causes of MPGN. Early identification of the primary or secondary causes of MPGN in children is vital.

Indexed as

C3 glomerulopathychildrenMembranoproliferative glomerulonephritis

Identifiers

PMID34976764
PMCPMC8649586

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