Evidence map›Paper›PMID 34976742›Full record

ArticleJournal of clinical & translational endocrinology2022

Use of estrogen supplementation is associated with higher quality of life scores in women with cystic fibrosis.

Malinda Wu, Neha Arora, Viranuj Sueblinvong, William R Hunt, Vin Tangpricha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & translational endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. The endocrine complications of cystic fibrosis.Nature reviews. Endocrinology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Malinda WuDivision of Endocrinology, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Neha AroraCollege of Arts and Sciences, Emory University, Atlanta, GA, United States.
Viranuj SueblinvongDivision of Pulmonary, Allergy, Critical Care and Sleep, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
William R HuntDivision of Pulmonary, Allergy, Critical Care and Sleep, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Vin TangprichaDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA and the Atlanta VA Medical Center, Decatur, GA, United States.
Emory University · USAtlanta VA Medical Center · USFlorida State University · US

Funding

Impact of alcohol on lung fibroblast regulation of the alveolar epithelial barrierR03AA027662 · NIAAA · EMORY UNIVERSITY · PI SUEBLINVONG, VIRANUJ · 2020 to 2021
$156k
NIAAA NIH HHS R03 AA027662
6 · The paper itself

Abstract

The association of estrogen supplementation use and quality of life in women with cystic fibrosis (CF) is not well characterized. In this cross-sectional study, women with CF completed quality of life questionnaires during a routine CF clinic visit. The use of estrogen supplementation was associated with higher quality of life scores in all domains of the CF questionnaire-revised (CFQ-R) and was significant in the role limitations and respiratory domains. Most participants who were not currently using estrogen supplementation had previously used estrogen supplementation. Most participants had used estrogen to regulate menses, prevent pregnancy and control symptoms around menses. Use of estrogen supplementation was not associated with differences in life-space mobility or screening for sexual dysfunction. This is the largest study to date investigating the association of estrogen supplementation and quality of life in women with CF. Prospective randomized studies are needed to clarify the association of estrogen supplementation and quality of life in women with CF.

Indexed as

BMI, Body mass indexCF, Cystic fibrosisCFQ-R, CF questionnaire-revisedCFTR, CF transmembrane conductance regulatorContraceptionCystic fibrosisEthinyl estradiolFDA, Food and Drug AdministrationFEV1, Forced expiratory volume in 1 secondFSFI-6, Female Sexual Function Index-6LSA, Life Space AssessmentMCID, Minimal clinical important differenceOCP, Oral contraceptive pillQuality of LifeSD, Standard deviationWomen’s healthYoung adult

Identifiers

PMID34976742
PMCPMC8688700
OpenAlexW4200028391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.