Evidence map›Paper›PMID 34976729›Full record

ArticleJournal of orthopaedic translation2021

A bio-inductive collagen scaffold that supports human primary tendon-derived cell growth for rotator cuff repair.

Peilin Chen, Allan Wang, William Haynes, Euphemie Landao-Bassonga, Clair Lee, Rui Ruan, William Breidahl, Behzad Shiroud Heidari, Christopher A Mitchell, Minghao Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024
    Review
  8. Article
  9. Multicellular Bioprinting of Biomimetic Inks for Tendon-to-Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Peilin ChenCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
Allan WangCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
William HaynesUmhlanga Ridge Orthopaedic Centre, Suite 514 5th Floor, Gateway Private Hospital, 36 Aurora Drive, Umhlanga, 4320, South Africa.
Euphemie Landao-BassongaCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
Clair LeeCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
Rui RuanCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
William BreidahlPerth Radiological Clinic, Perth, Australia.
Behzad Shiroud HeidariPerron Institute for Neurological and Translational Science, Perth, Western Australia, 6009, Australia.
Christopher A MitchellCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
Minghao ZhengCentre for Orthopaedic Research, The UWA Medical School, The University of Western Australia, Crawley, WA, 6009, Australia.
Australian Research Council · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRotator Cuff (RC) tendon tearing is a common clinical problem and there is a high incidence of revision surgery due to re-tearing. In an effort to improve patient outcome and reduce surgical revision, scaffolds have been widely used for augmentation of RC repairs. However, little is known about how scaffolds support tendon stem cell growth or facilitate tendon regeneration. The purpose of this study is to evaluate the structural and biological properties of a bioactive collagen scaffold (BCS) with the potential to promote tendon repair. Additionally, we conducted a pilot clinical study to assess the safety and feasibility of using the BCS for repair of RC tears.

methodsA series of physical, ultrastructural, molecular and

resultsThe BCS consists of highly purified type-I collagen, in bundles of varying diameter, arranged in a higher order tri-laminar structure. BCS have minimal immunogenicity, being cell and essentially DNA-free as well as uniformly negative for the porcine α-Gal protein. BCS seeded with human primary tendon-derived cells and exposed to 6% uniaxial loading conditions

conclusionThe BCS is composed of type-I collagen that is free of immunogenic proteins and supports tendon-derived cell growth under mechanical loading THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: The results of this study indicate that this bioactive collagen scaffold has unique properties for supporting tendon growth and that it is non-immunogenic. The clinical study further confirms that the scaffold is a promising biological device for augment of human rotator cuff repairs.

Indexed as

Cell cultureCollagen-based scaffoldRotator cuff repairShoulderTendon-derived cells

Identifiers

PMID34976729
PMCPMC8671806
OpenAlexW4200251580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.