ArticleResults in physics2022
Piecewise differentiation of the fractional order CAR-T cells-SARS-2 virus model.
Article in Results in physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Orthonormal piecewise Vieta-Lucas functions for the numerical solution of the one- and two-dimensional piecewise fractional Galilei invariant advection-diffusion equations.Journal of advanced research · 2023Article
- Piecewise Business Bubble System under Classical and Nonsingular Kernel of Mittag-Leffler Law.Entropy (Basel, Switzerland) · 2023Article
- Real-World COVID-19 Vaccine Protection Rates against Infection in the Delta and Omicron Eras.Research (Washington, D.C.) · 2023Article
- Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables.Frontiers in immunology · 2023Article
- Modeling the crossover behavior of the bacterial infection with the COVID-19 epidemics.Results in physics · 2022Article
- Antiviral Cell Products against COVID-19: Learning Lessons from Previous Research in Anti-Infective Cell-Based Agents.Biomedicines · 2022Review
- Forecasting of the efficiency of monoclonal therapy in the treatment of CoViD-19 induced by the Omicron variant of SARS-CoV2.Results in physics · 2022Article
- China public emotion analysis under normalization of COVID-19 epidemic: Using Sina Weibo.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pandemic caused by the SARS-CoV2 virus has prompted research into new therapeutic solutions that can be used to treat the CoVid-19 syndrome. As part of this research, immunotherapy, first developed against cancer, is offering new therapeutic horizons also against viral infections. CAR technology, with the production of CAR-T cells (adoptive immunotherapy), has shown applicability in the field of HIV viral infections through second generation CAR-T cells implemented with the "CD4CAR" system with a viral fusion inhibitor. In addition, to avoid the immunoescape of the virus, bi- or trispecific CAR receptors have been developed. Our research group hypothesizes the use of this immunotherapy system against SARS-CoV2, admitting the appropriate adjustments concerning the target-epitope and a possible remodeling of the nuclease related to the action of this virus. For a more in-depth analysis of this hypothesis, a mathematical model has been developed which, starting from the fractional derivative Caputo, creates a system of equations that describes the interactions between CAR-T cells, memory cells, and cells infected with SARS-CoV2. Through an analysis of the existence and non-negativity of the solutions, the hypothesis is stabilized; then is further demonstrated through the use of the piece-wise derivative and the consequent application of the formula of Newton polynomial interpolation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.