Evidence map›Paper›PMID 34976582›Full record

ArticleNanotheranostics2022

Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window.

Wonjun Yim, Raina M Borum, Jiajing Zhou, Yash Mantri, Zhuohong Wu, Jingcheng Zhou, Zhicheng Jin, Matthew Creyer, Jesse V Jokerst

Abstract read
In one paragraph

Article in Nanotheranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  9. Review
  10. Article
  11. Nanostructures as Photothermal Agents in Tumor Treatment.Molecules (Basel, Switzerland) · 2022
    Review
  12. CuS-Pharmaceutics · 2022
    Article
  13. Article
  14. Review
  15. Photoacoustic Enhancement of Ferricyanide-Treated Silver Chalcogenide-Coated Gold Nanorods.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wonjun YimMaterials Science and Engineering Program, University of California San Diego, La Jolla, California, 92093, United States.
Raina M BorumDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093, United States.
Jiajing ZhouDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093, United States.
Yash MantriDepartment of Bioengineering, University of California San Diego, La Jolla, California, 92093, United States.
Zhuohong WuDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093, United States.
Jingcheng ZhouDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093, United States.
Zhicheng JinDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093, United States.
Matthew CreyerDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093, United States.
Jesse V JokerstMaterials Science and Engineering Program, University of California San Diego, La Jolla, California, 92093, United States.

Funding

Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
MANTA ViewSizer 3011 Nanoparticle Characterization SystemS10OD023555 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2018 to 2018
$137k
NCI NIH HHS T32 CA153915NHLBI NIH HHS DP2 HL137187NIH HHS S10 OD021821NIH HHS S10 OD023527NIH HHS S10 OD023555
6 · The paper itself

Abstract

Gold nanorods (GNRs) have attracted great interest for photo-mediated biomedicines due to their tunable and high optical absorption, high photothermal conversion efficiency and facile surface modifiability. GNRs that have efficient absorption in second near-infrared (NIR-II) window hold further promise in bio-applications due to low background signal from tissue and deep tissue penetration. However, bare GNRs readily undergo shape deformation (termed as 'melting effect') during the laser illumination losing their unique localized surface plasmon resonance (LSPR) properties, which subsequently leads to PA signal attenuation and decreased photothermal efficiency. Polydopamine (PDA) is a robust synthetic melanin that has broad absorption and high photothermal conversion. Herein, we coated GNRs with PDA to prepare photothermally robust GNR@PDA hybrids for enhanced photo-mediated theranostic agents. Ultrasmall GNRs (SGNRs) and conventional large GNRs (LGNRs) that possess similar LSPR characteristics as well as GNR@PDA hybrids were compared side-by-side in terms of the size-dependent photoacoustic (PA) imaging, photothermal therapy (PTT), and structural stability.

Indexed as

NanotubesPhotoacoustic TechniquesCell Line, TumorGoldIndolesPhotothermal TherapyPolymersGoldIndolespolydopaminePolymerscore-shell structureminiature gold nanorodsecond near-infraredsynthetic melanin

Identifiers

PMID34976582
PMCPMC8671965

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.