Evidence map›Paper›PMID 34976578›Full record

ReviewNanotheranostics2022

Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications.

Bohdan Andreiuk, Fay Nicolson, Louise M Clark, Sajanlal R Panikkanvalappil, Kenry, Mohammad Rashidian, Stefan Harmsen, Moritz F Kircher

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nanotheranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  9. Growing Gold Nanostars on 3D Hydrogel Surfaces.Chemistry of materials : a publication of the American Chemical Society · 2024
    Article
  10. Review
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  16. Article
  17. Functionalization of Nanomaterials for Skin Cancer Theranostics.Frontiers in bioengineering and biotechnology · 2022
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bohdan AndreiukDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
Fay NicolsonDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
Louise M ClarkDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
Sajanlal R PanikkanvalappilDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
KenryDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
Mohammad RashidianDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.
Stefan HarmsenDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Moritz F KircherDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.

Funding

Ultrabright Theranostic SERRS Nanoparticles for Gastrointestinal EndoscopyR01CA222836 · NCI · STANFORD UNIVERSITY · PI ROGALLA, STEPHAN · 2018 to 2023
$3.4M
MRI-Photoacoustic-Raman Nanostars for Pre- and Intraoperative Multimodal ImagingR01EB017748 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI KIRCHER, MORITZ FLORIAN · 2014 to 2017
$1.6M
NCI NIH HHS R01 CA222836NIBIB NIH HHS R01 EB017748
6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) nanotags hold a unique place among bioimaging contrast agents due to their fingerprint-like spectra, which provide one of the highest degrees of detection specificity. However, in order to achieve a sufficiently high signal intensity, targeting capabilities, and biocompatibility, all components of nanotags must be rationally designed and tailored to a specific application. Design parameters include fine-tuning the properties of the plasmonic core as well as optimizing the choice of Raman reporter molecule, surface coating, and targeting moieties for the intended application. This review introduces readers to the principles of SERS nanotag design and discusses both established and emerging protocols of their synthesis, with a specific focus on the construction of SERS nanotags in the context of bioimaging and theranostics.

Indexed as

GoldSpectrum Analysis, RamanGoldcancer imaginggold nanostar synthesisnear-infrared dyeSurface-enhanced Raman scattering

Identifiers

PMID34976578
PMCPMC8671966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.