Evidence map›Paper›PMID 34976356›Full record

ArticleChemical science2021

SiRNA-templated 3D framework nucleic acids for chemotactic recognition, and programmable and visualized precise delivery for synergistic cancer therapy.

Jingjing Li, Ying Zhang, Jianghui Sun, Jin Ouyang, Na Na

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jingjing LiKey Laboratory of Radiopharmaceuticals, Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University Beijing 100875 China nana@bnu.edu.cn.
Ying ZhangKey Laboratory of Radiopharmaceuticals, Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University Beijing 100875 China nana@bnu.edu.cn.
Jianghui SunKey Laboratory of Radiopharmaceuticals, Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University Beijing 100875 China nana@bnu.edu.cn.
Jin OuyangKey Laboratory of Radiopharmaceuticals, Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University Beijing 100875 China nana@bnu.edu.cn.ORCID https://orcid.org/0000-0002-0286-0798
Na NaKey Laboratory of Radiopharmaceuticals, Key Laboratory of Theoretical and Computational Photochemistry, College of Chemistry, Beijing Normal University Beijing 100875 China nana@bnu.edu.cn.ORCID https://orcid.org/0000-0002-0474-8409
Beijing Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developments in framework nucleic acids (FNAs) are limited by complicated synthesis, by-product interference, and low framework utilization. Herein, simple core-shell spherical 3D FNAs (ST-SFNAs) preparation is presented based on siRNA-templated linear polymerization followed by hybridization chain reaction branched polymerization. Without by-products, all components exhibited their special functions to obtain high space utilization of ST-SFNAs. ST-SFNAs were covered by catalase and folic acid-functionalized liposome membranes. The catalase endowed ST-SFNAs with chemotactic activities in the H

Identifiers

PMID34976356
PMCPMC8635176
OpenAlexW3212823664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.