ArticleChemical science2021
The electrostatic origins of specific ion effects: quantifying the Hofmeister series for anions.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Agglomeration Efficacies of Simple Salts on Charged Gold Nanocrystals with Mixed Ligand Shells: A High-Throughput Study.ACS materials Au · 2026Article
- Fine Tuning of the Arrangement of Non-Close-Packed Structures: Specific Ion Effects of Lanthanide Cations.ACS omega · 2026Article
- Specific ion effects on ion transport in charged polymer membranes.Science advances · 2026Article
- Hydrophilicity controls thermodiffusion in alkylammonium chlorides.The European physical journal. E, Soft matter · 2026Article
- Highly reconfigurable neuronlike conductive networks through nanophase structure engineering.Nature communications · 2025Article
- Unraveling the Molecular Pathways for Structure "Making" and "Breaking" by Ions in Water.Journal of the American Chemical Society · 2025Article
- Thermophobic diffusion becomes dominant in ultra-dilute alkali halide aqueous solutions.Communications chemistry · 2025Article
- Counterion-Mediated Luminophore Dimerization.Angewandte Chemie (International ed. in English) · 2025Article
- Solvent and Ion-Mediated Behavior of a Thermoresponsive Brush: Specific Ion Effects in Methanol-Water Electrolytes.Macromolecular rapid communications · 2025Article
- Remarks on Life Feasibility on the Red Planet.Microorganisms · 2025Review
- The inductive effect does not explain electron density in haloacetates: are our textbooks wrong?Chemical science · 2025Article
- Enhancing Thermogalvanic Efficiency through Electrostatic Interaction in Cationic Hydrogels.ACS applied energy materials · 2025Article
- Self-Diffusion of Star and Linear Polyelectrolytes in Salt-Free and Salt Solutions.Macromolecules · 2025Article
- ChemFET Anion Sensor Based on MOF Nanoparticles.ChemPlusChem · 2025Article
- Specific Ion Effects in Hydrogels.Molecules (Basel, Switzerland) · 2024Review
- Zeolite membrane with sub-nanofluidic channels for superior blue energy harvesting.Nature communications · 2024Article
- In the Beginning: Let Hydration Be Coded in Proteins for Manifestation and Modulation by Salts and Adenosine Triphosphate.International journal of molecular sciences · 2024Review
- NMR Dynamic View of the Stabilization of the WW4 Domain by Neutral NaCl and Kosmotropic NaInternational journal of molecular sciences · 2024Article
- NMR Dynamic View of the Destabilization of WW4 Domain by Chaotropic GdmCl and NaSCN.International journal of molecular sciences · 2024Article
- Counter Anion Type Influences the Glass Transition Temperature of Polyelectrolyte Complexes.Macromolecules · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life as we know it is dependent upon water, or more specifically salty water. Without dissolved ions, the interactions between biological molecules are insufficiently complex to support life. This complexity is intimately tied to the variation in properties induced by the presence of different ions. These specific ion effects, widely known as Hofmeister effects, have been known for more than 100 years. They are ubiquitous throughout the chemical, biological and physical sciences. The origin of these effects and their relative strengths is still hotly debated. Here we reconsider the origins of specific ion effects through the lens of Coulomb interactions and establish a foundation for anion effects in aqueous and non-aqueous environments. We show that, for anions, the Hofmeister series can be explained and quantified by consideration of site-specific electrostatic interactions. This can simply be approximated by the radial charge density of the anion, which we have calculated for commonly reported ions. This broadly quantifies previously unpredictable specific ion effects, including those known to influence solution properties, virus activities and reaction rates. Furthermore, in non-aqueous solvents, the relative magnitude of the anion series is dependent on the Lewis acidity of the solvent, as measured by the Gutmann Acceptor Number. Analogous SIEs for cations bear limited correlation with their radial charge density, highlighting a fundamental asymmetry in the origins of specific ion effects for anions and cations, due to competing non-Coulombic phenomena.
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Registered trials
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