Evidence map›Paper›PMID 34976317›Full record

ArticleComputational and structural biotechnology journal2022

Application of microfluidic systems in modelling impacts of environmental structure on stress-sensing by individual microbial cells.

Harry J Harvey, Mykyta V Chubynsky, James E Sprittles, Leslie M Shor, Sacha J Mooney, Ricky D Wildman, Simon V Avery

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Harry J HarveySchool of Life Sciences, University of Nottingham, Nottingham, UK.
Mykyta V ChubynskyMathematics Institute, University of Warwick, Coventry, UK.
James E SprittlesMathematics Institute, University of Warwick, Coventry, UK.
Leslie M ShorDepartment of Chemical and Biomolecular Engineering, University of Connecticut, USA.
Sacha J MooneySchool of Biosciences, University of Nottingham, Nottingham, UK.
Ricky D WildmanFaculty of Engineering, University of Nottingham, Nottingham, UK.
Simon V AverySchool of Life Sciences, University of Nottingham, Nottingham, UK.
University of Nottingham · GBUniversity of Warwick · GBUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental structure describes physical structure that can determine heterogenous spatial distribution of biotic and abiotic (nutrients, stressors etc.) components of a microorganism's microenvironment. This study investigated the impact of micrometre-scale structure on microbial stress sensing, using yeast cells exposed to copper in microfluidic devices comprising either complex soil-like architectures or simplified environmental structures. In the soil micromodels, the responses of individual cells to inflowing medium supplemented with high copper (using cells expressing a copper-responsive

Indexed as

Copper stressEnvironmental heterogeneityFluid flow modellingSaccharomyces cerevisiaeStress responseStructured microenvironments

Identifiers

PMID34976317
PMCPMC8689086
OpenAlexW3215512090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.