Evidence map›Paper›PMID 34976198›Full record

ArticleTheranostics2022

Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury.

Hong-Ru Chen, Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. ΔJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Hong-Ru ChenDepartment of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, VA, USA.
Ching-Wen ChenDepartment of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, VA, USA.
Yi-Min KuoDepartment of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.
Brandon ChenUniversity of Louisville School of Medicine, Louisville, KY, USA.
Irena S KuanSt. Louis University School of Medicine, St. Louis, MO, USA.
Henry HuangDepartment of Anesthesiology, Rhode Island Hospital, Providence, RI, USA.
Jolly LeeEmory University School of Medicine, Atlanta, GA, USA.
Neil AnthonyEmory Integrated Cellular Imaging, Atlanta, GA, USA.
Chia-Yi KuanDepartment of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia School of Medicine, Charlottesville, VA, USA.
Yu-Yo SunInstitute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
University of Virginia · USEmory University · USNational Sun Yat-sen University · TWRhode Island Hospital · USSaint Louis University · USUniversity of Louisville · US

Funding

Creatine Transporter Deficiency and Brain EnergeticsR01NS108763 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2018 to 2022
$2.3M
Crosstalk of Innate and Adaptive Immunity in Infection-Sensitized Neonatal HIER01NS095064 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2016 to 2020
$1.7M
Mechanisms and Experimental Therapy of Perinatal Cerebral HemorrhageR01NS084744 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2014 to 2018
$1.7M
Thrombolytic Stroke Therapy in Humanized Sickle MiceR21NS106592 · NINDS · UNIVERSITY OF VIRGINIA · PI SUN, YU-YO · 2018 to 2019
$457k
Monocyte-Derived Microglia after Maternal Immune Activation and Neonatal BrainInjuryR21NS100419 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2017 to 2018
$429k
NINDS NIH HHS R01 NS084744NINDS NIH HHS R01 NS095064NINDS NIH HHS R01 NS108763NINDS NIH HHS R21 NS100419NINDS NIH HHS R21 NS106592
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adoptive TransferAnimalsAnimals, NewbornBrain InjuriesCell MovementCells, CulturedChoroid PlexusFemaleHypoxia-Ischemia, BrainInflammationMaleMiceMice, Inbred C57BLMicrogliaMonocytesNeuroinflammatory DiseasesCcr2 protein, mouseReceptors, CCR2CCR2chorioamnionitishypoxic ischemic encephalopathy (HIE)microgliamonocyte-derived macrophagesneuroinflammation

Identifiers

PMID34976198
PMCPMC8692901
OpenAlexW4200618165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.