Evidence map›Paper›PMID 34976093›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Hepatoprotective Effects of (-) Epicatechin in CCl

Khadijah B Alkinani, Ehab M M Ali, Turki M Al-Shaikh, Jalaluddin A Awlia Khan, Tahani M Al-Naomasi, Soad S Ali, Asaad A Abduljawad, Osama F Mosa, Tariq A Zafar

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Polyphenolic profile, hepatoprotective evaluation, and molecular docking study of three palm tree species (Family Arecaceae).Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Article
  8. Article
  9. Advancements inFoods (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Khadijah B AlkinaniPublic Health Department, Health Sciences College at Leith, Umm Al Qura University, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0003-4895-9803
Ehab M M AliDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-2475-0645
Turki M Al-ShaikhDepartment of Biology, College of Science and Arts at Khulis, University of Jeddah, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-4469-8581
Jalaluddin A Awlia KhanDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0003-2319-4023
Tahani M Al-NaomasiChemistry Department, Faculty of Science, Hail University, Hail, Saudi Arabia.ORCID https://orcid.org/0000-0001-5585-8520
Soad S AliFaculty of Medicine, Assiut University, Asyut, Egypt.ORCID https://orcid.org/0000-0002-2434-2027
Asaad A AbduljawadPublic Health Department, Health Sciences College at Leith, Umm Al Qura University, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0002-1894-5382
Osama F MosaPublic Health Department, Health Sciences College at Leith, Umm Al Qura University, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0001-5052-7116
Tariq A ZafarPublic Health Department, Health Sciences College at Leith, Umm Al Qura University, Makkah, Saudi Arabia.ORCID https://orcid.org/0000-0001-5866-5177
Umm al-Qura University · SAKing Abdulaziz University · SAUniversity of Ha'il · SAUniversity of Jeddah · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective(-) Epicatechin (EP) is a naturally occurring antioxidant flavonoid found in some green plants. The current study was designed to evaluate the potential role of antioxidant mechanisms in the hepatoprotective properties of EP using the carbon tetrachloride (CCl MATERIALS AND

methodsRats (

resultsTest compound EP and standard drug silymarin (SILY) considerably reduced liver function enzyme levels in the blood, which were raised by CCl

conclusionsThe results of this study revealed a significant protective efficacy of EP against CCl

Identifiers

PMID34976093
PMCPMC8716200
OpenAlexW4200257797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.