Evidence map›Paper›PMID 34976051›Full record

ArticleInternational journal of endocrinology2021

MEK1/2 Inhibitor (GDC0623) Promotes Osteogenic Differentiation of Primary Osteoblasts Inhibited by IL-1

Zeng-Qiao Zhang, Xiao-Shen Hu, Ye-Chen Lu, Jun-Peng Zhang, Wen-Yao Li, Wei-Yang Zhang, Wei Feng, Dao-Fang Ding, Jian-Guang Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zeng-Qiao ZhangSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiao-Shen HuSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ye-Chen LuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jun-Peng ZhangSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wen-Yao LiSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei-Yang ZhangSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Wei FengSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dao-Fang DingSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-4056-142X
Jian-Guang XuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-0601-3403
Shanghai University of Traditional Chinese Medicine · CNChengdu Sport University · CNChengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe evaluated the effects and mechanisms of GDC0623 on osteogenic differentiation of osteoblasts induced by IL-1

resultsRelative to the control group, IL-1

conclusionInhibition of Jak-Stat3 pathway by C188-9 downregulated the expression levels of MMP9 and MMP13, activated MEK-Erk1/2 pathway, and inhibited osteogenic differentiation.

Identifiers

PMID34976051
PMCPMC8716208
OpenAlexW4200576601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.