Evidence map›Paper›PMID 34976016›Full record

ArticleFrontiers in genetics2021

Mitochondrial Genome Study Identifies Association Between Primary Open-Angle Glaucoma and Variants in

Valeria Lo Faro, Ilja M Nolte, Jacoline B Ten Brink, Harold Snieder, Nomdo M Jansonius, Arthur A Bergen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Glaucomatous retinal ganglion cells: death and protection.International journal of ophthalmology · 2025
    Review
  7. The role of RGC degeneration in the pathogenesis of glaucoma.International journal of biological sciences · 2025
    Review
  8. Protein misfolding and mitochondrial dysfunction in glaucoma.Frontiers in cell and developmental biology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Mitochondrial dysfunction in glaucomatous degeneration.International journal of ophthalmology · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Valeria Lo FaroDepartment of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Jacoline B Ten BrinkDepartment of Clinical Genetics, Amsterdam University Medical Center (AMC), Amsterdam, Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Nomdo M JansoniusDepartment of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Arthur A BergenDepartment of Clinical Genetics, Amsterdam University Medical Center (AMC), Amsterdam, Netherlands.
Amsterdam University Medical Centers · NLUniversity Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

genetic association studyhaplogroup Kmitochondrial haplogroupmitochondrial polymorphismMT-CYBMT-ND4primary open-angle glaucoma (POAG)

Identifiers

PMID34976016
PMCPMC8719162
OpenAlexW4200003428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.