Evidence map›Paper›PMID 34975897›Full record

ArticleFrontiers in immunology2021

Anti-SARS-CoV-2 Immunoglobulin Isotypes, and Neutralization Activity Against Viral Variants, According to BNT162b2-Vaccination and Infection History.

Maciej Tarkowski, Wilco de Jager, Marco Schiuma, Alice Covizzi, Alessia Lai, Arianna Gabrieli, Mario Corbellino, Annalisa Bergna, Carla Della Ventura, Massimo Galli and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Maciej TarkowskiDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Wilco de JagerLuminex B.V., Hertogenbosch, Netherlands.
Marco SchiumaDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Alice CovizziDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Alessia LaiDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Arianna GabrieliDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Mario CorbellinoDivision of Infectious Diseases, Aziende Socio Sanitarie Territoriali (ASST) Fatebenefratelli Sacco Hospital, Milan, Italy.
Annalisa BergnaDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Carla Della VenturaDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Massimo GalliDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Agostino RivaDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
Spinello AntinoriDepartment of Biomedical and Clinical Sciences L. Sacco, Università degli Studi di Milano, Milan, Italy.
University of Milan · ITASST Fatebenefratelli Sacco · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To compare SARS-CoV-2 antigen-specific antibody production and plasma neutralizing capacity against B.1 wild-type-like strain, and Gamma/P.1 and Delta/B.1.617.2 variants-of-concern, in subjects with different Covid-19 disease and vaccination histories. Methods: Adult subjects were: 1) Unvaccinated/hospitalized for Covid-19; 2) Covid-19-recovered followed by one BNT162b2 vaccine dose; and 3) Covid-19-naïve/2-dose BNT162b2 vaccinated. Multiplex Luminex Results: Maximum anti-RBD IgG levels were similar in Covid Conclusion: These findings support SARS-CoV-2 mRNA vaccine usefulness regardless of Covid-19 history, and confirm remarkable protection provided by a single vaccine dose in people who have recovered from Covid-19.

Indexed as

AdultAgedAged, 80 and overAnimalsAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineChlorocebus aethiopsCOVID-19FemaleHumansImmunoassayImmunoglobulin AImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineImmunoglobulin AImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MSpike Glycoprotein, CoronavirusbeadcoronavirusCOVID-19fluorescencemultiplex immunoassayneutralization assaySARS-CoV-2serological assay

Identifiers

PMID34975897
PMCPMC8718396
OpenAlexW4200030804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.