Evidence map›Paper›PMID 34975889›Full record

ArticleFrontiers in immunology2021

Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis.

David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
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  7. FermentedInternational journal of medical sciences · 2026
    Article
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  17. Multi-omics analysis ofFrontiers in microbiology · 2025
    Article
  18. Article
  19. Anti-Inflammatory Effect of Medicinal FungusFood technology and biotechnology · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

David AchudhanGraduate Institute of Biomedical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Shan-Chi LiuDepartment of Medical Education and Research, China Medical University Beigang Hospital, Yunlin, Taiwan.
Yen-You LinDepartment of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.
Chien-Chung HuangGraduate Institute of Biomedical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Chun-Hao TsaiDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan.
Chih-Yuan KoDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.
I-Ping ChiangDepartment of Pathology, China Medical University Hospital, Taichung, Taiwan.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
Chih-Hsin TangGraduate Institute of Biomedical Science, College of Medicine, China Medical University, Taichung, Taiwan.
China Medical University · TWChina Medical University Hospital · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracts from Taiwan's traditional medicinal mushroom,

Indexed as

AnimalsArthritis, RheumatoidCartilageCells, CulturedCholestenesCytokinesFibroblastsHumansInterleukin-1betaInterleukin-8MiceMice, Inbred C57BLNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSynovial Membraneantcin KCholestenesCytokinesInterleukin-1betaInterleukin-8NF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTumor Necrosis Factor-alphaantcin KAntrodia cinnamomeacollagen-induced arthritisinterleukin 1 betainterleukin 8rheumatoid arthritisrheumatoid arthritis synovial fibroblasttumor necrosis factor alpha

Identifiers

PMID34975889
PMCPMC8714747
OpenAlexW4200231350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.