Evidence map›Paper›PMID 34975843›Full record

ArticleFrontiers in immunology2021

Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma.

Simon Le Gallou, Faustine Lhomme, Jonathan M Irish, Anna Mingam, Celine Pangault, Celine Monvoisin, Juliette Ferrant, Imane Azzaoui, Delphine Rossille, Krimo Bouabdallah and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Heterogeneity of monocytes in cancer.American journal of cancer research · 2025
    Review
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  16. Pro- vs. Anti-Inflammatory Features of Monocyte Subsets in Glioma Patients.International journal of molecular sciences · 2023
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 2 countries.

Simon Le GallouCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Faustine LhommeCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Jonathan M IrishDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Anna MingamCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Celine PangaultCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Celine MonvoisinInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche U1236, Université Rennes 1, Etablissement Français du Sang Bretagne, Rennes, France.
Juliette FerrantInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche U1236, Université Rennes 1, Etablissement Français du Sang Bretagne, Rennes, France.
Imane AzzaouiCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Delphine RossilleCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Krimo BouabdallahCentre Hospitalier Universitaire de Bordeaux, Service d'Hématologie Clinique, Bordeaux, France.
Gandhi DamajCentre Hospitalier Universitaire de Caen, Service d'Hématologie Clinique, Caen, France.
Guillaume CartronCentre Hospitalier Universitaire de Montpellier, Service d'Hématologie Clinique, Montpellier, France.
Pascal GodmerCentre Hospitalier de Bretagne Atlantique, Unité d'Hématologie Clinique, Vannes, France.
Steven Le GouillCentre Hospitalier Universitaire de Nantes, Service d'Hématologie Clinique, Institut National de la Sante et de la Recherche Medicale, Centre de Recherche en Cancérologie et Immunologie Nantes Angers (INSERM CCRCINA) Nantes-Angers, NeXT Université de Nantes, Nantes, France.
René-Olivier CasasnovasCentre Hospitalier Universitaire de Dijon, Service d'Hématologie Clinique, Dijon, France.
Thierry Jo MolinaAsistance Publique, Hopitaux de Paris (APHP), Necker, Service d'Anatomopathologie, Sorbonne Université, Paris, France.
Roch HouotInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche U1236, Université Rennes 1, Etablissement Français du Sang Bretagne, Rennes, France.
Thierry LamyInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche U1236, Université Rennes 1, Etablissement Français du Sang Bretagne, Rennes, France.
Karin TarteCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Thierry FestCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Mikael RousselCentre Hospitalier Universitaire de Rennes, Pôle Biologie, Rennes, France.
Inserm · FRCentre Hospitalier Universitaire de Rennes · FRVanderbilt University · USCentre hospitalier Bretagne Atlantique · FRCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Caen Normandie · FRCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier Universitaire de Nantes · FRCHU Dijon Bourgogne · FRHôpital Necker-Enfants Malades · FR

Funding

Single Cell Methods for Bioeffector Discovery and AnalysisR01CA226833 · NCI · VANDERBILT UNIVERSITY · PI BRIAN O BACHMANN, Jonathan Michael Irish · 2019 to 2026
$6.1M
NCI NIH HHS R01 CA226833
6 · The paper itself

Abstract

Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance in DLBCL has been poorly explored. Herein, we broadly assessed circulating monocyte heterogeneity in 91 DLBCL patients. Classical- (cMO, CD14

Indexed as

AdultAgedFemaleHumansImmunophenotypingLymphoma, Large B-Cell, DiffuseMaleMiddle AgedMonocytesB cell lymphomabiomarkerDLBCLimmune suppressionmonocyte

Identifiers

PMID34975843
PMCPMC8716558
OpenAlexW4225642244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.