Evidence map›Paper›PMID 34975806›Full record

ReviewFrontiers in microbiology2021

Marine Invertebrate Peptides: Antimicrobial Peptides.

Ran Wu, Jiri Patocka, Eugenie Nepovimova, Patrik Oleksak, Martin Valis, Wenda Wu, Kamil Kuca

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 84 citations in OpenAlex.

  1. Review
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  6. SC2-3, a Marine Nutrient Glycopeptide fromFoods (Basel, Switzerland) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ran WuMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Jiri PatockaDepartment of Radiology and Toxicology, Faculty of Health and Social Studies, University of South Bohemia in České Budějovice, České Budějovice, Czechia.
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czechia.
Patrik OleksakDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czechia.
Martin ValisDepartment of Neurology, Faculty of Medicine, University Hospital Hradec Králové, Charles University, Hradec Králové, Czechia.
Wenda WuMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Kamil KucaBiomedical Research Centre, University Hospital Hradec Králové, Hradec Králové, Czechia.
University of Hradec Králové · CZCharles University · CZNanjing Agricultural University · CNUniversity of South Bohemia in České Budějovice · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides are an important component of many organisms' innate immune system, with a good inhibitory or killing effect against the invading pathogens. As a type of biological polypeptide with natural immune activities, antimicrobial peptides have a broad spectrum of antibacterial, antiviral, and antitumor activities. Nevertheless, these peptides cause no harm to the organisms themselves. Compared with traditional antibiotics, antimicrobial peptides have the advantage of not producing drug resistance and have a unique antibacterial mechanism, which has attracted widespread attention. In this study, marine invertebrates were classified into arthropods, annelids, mollusks, cnidarians, and tunicata. We then analyzed the types, sources and antimicrobial activities of the antimicrobial peptides in each group. We also reviewed the immune mechanism from three aspects: membrane-targeted direct killing effects, non-membrane targeting effects and immunomodulatory effects. Finally, we discussed their applications and the existing problems facing antimicrobial peptides in actual production. The results are expected to provide theoretical support for future research and applications of antimicrobial peptides in marine invertebrates.

Indexed as

activityantimicrobial peptidesmarinemarine invertebratemechanism

Identifiers

PMID34975806
PMCPMC8719109
OpenAlexW4200293671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.