Evidence map›Paper›PMID 34975766›Full record

ArticleFrontiers in endocrinology2021

Live Birth Rate in Patients With Premature Ovarian Insufficiency During Long-Term Follow-Up Under Hormone Replacement With or Without Ovarian Stimulation.

Bunpei Ishizuka, Masataka Furuya, Machiko Kimura, Eri Kamioka, Kazuhiro Kawamura

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Clinical practice guidelines for the management of differences of sex development in Japan.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Primary Ovarian Insufficiency, Bone Health, and Other Outcomes in Adolescents.Obstetrics and gynecology clinics of North America · 2024
    Review
  11. Article
  12. Article
  13. Effects of chemicalHuman reproduction open · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bunpei IshizukaRose Ladies Clinic, Tokyo, Japan.
Masataka FuruyaRose Ladies Clinic, Tokyo, Japan.
Machiko KimuraRose Ladies Clinic, Tokyo, Japan.
Eri KamiokaRose Ladies Clinic, Tokyo, Japan.
Kazuhiro KawamuraDepartment of Obstetrics and Gynecology, Advanced Reproductive Medicine Research Center, International University of Health and Welfare School of Medicine, Chiba, Japan.
Tokyo Rosai Hospital · JPInternational University of Health and Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed data from 466 patients with premature ovarian insufficiency (POI) who wished to have a biological child and were followed up while undergoing hormone replacement (HR) therapy with or without ovarian stimulation (OS) between April 2014 and December 2020. OS was conducted in 6891 cycles in 429 patients (Group OS), whereas only HR (Group HR) was conducted in 1117 cycles in 37 patients. The follicle growth rate was 48.3% (207/429) per patient in Group OS and 5.4% (2/37) in Group HR (p<0.01). There were 51 live births (LBs) in 50 patients during follow-up. In Group OS, the LB rate was 5.8% (47/807) in cycles where

Indexed as

Live BirthAdultCohort StudiesEstrogen Replacement TherapyFemaleFollow-Up StudiesHumansInfertility, FemaleMaleOvulation InductionPregnancyPrimary Ovarian InsufficiencyRetrospective StudiesSemen AnalysisTime Factorsinfertilitylive birth rateovarian stimulationpregnancy ratepremature ovarian insufficiency

Identifiers

PMID34975766
PMCPMC8719621
OpenAlexW4200613698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.