Evidence map›Paper›PMID 34975759›Full record

ReviewFrontiers in endocrinology2021

Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure.

Nicole Mohajer, Erika M Joloya, Jeongbin Seo, Toshi Shioda, Bruce Blumberg

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  5. Obesogens: a unifying theory for the global rise in obesity.International journal of obesity (2005) · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Stress and human health in diabetes: A report from the 19Journal of clinical and translational science · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicole MohajerDepartment of Pharmaceutical Sciences, University of California, Irvine, CA, United States.
Erika M JoloyaDepartment of Developmental and Cell Biology, University of California, Irvine, CA, United States.
Jeongbin SeoDepartment of Developmental and Cell Biology, University of California, Irvine, CA, United States.
Toshi ShiodaCenter for Cancer Research, Massachusetts General Hospital, Charlestown, MA, United States.
Bruce BlumbergDepartment of Pharmaceutical Sciences, University of California, Irvine, CA, United States.
University of California, Irvine · USMassachusetts General Hospital · US

Funding

Transgenerational obesity caused by ancestral exposure to obesogens in utero: changes in germline genomic architecture, roles of gonadal somatic cells, and metabolomic analysis of sexual dimorphismR01ES023316 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE BLUMBERG, TOSHIHIRO SHIODA · 2013 to 2026
$8.3M
Interactions between prenatal obesogen exposure and Total Western diet lead to a transgenerational thrifty phenotype: functional and epigenomic analysis of effects in fat and liverR01ES031139 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLUMBERG, BRUCE, SHIODA, TOSHIHIRO · 2020 to 2025
$2.4M
NIEHS NIH HHS R01 ES023316NIEHS NIH HHS R01 ES031139
6 · The paper itself

Abstract

Obesity and metabolic disorders have become a worldwide pandemic affecting millions of people. Although obesity is a multifaceted disease, there is growing evidence supporting the obesogen hypothesis, which proposes that exposure to a subset of endocrine disrupting chemicals (EDCs), known as obesogens, promotes obesity. While these effects can be observed

Indexed as

AnimalsChromatinDNA MethylationEndocrine DisruptorsEnvironmental ExposureEpigenesis, GeneticFemaleGenetic Predisposition to DiseaseHistonesHumansInheritance PatternsMaleMethylationObesityPhenotypeChromatinEndocrine DisruptorsHistonesEDCendocrine disrupting chemicalsepigeneticsobesityobesogentransgenerationaltransgenerational inheritance

Identifiers

PMID34975759
PMCPMC8716683
OpenAlexW4200623739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.