Evidence map›Paper›PMID 34975732›Full record

ArticleFrontiers in neurology2021

Gender Differences in 3-Month Outcomes of Erenumab Treatment-Study on Efficacy and Safety of Treatment With Erenumab in Men.

Raffaele Ornello, Carlo Baraldi, Simona Guerzoni, Giorgio Lambru, Matteo Fuccaro, Bianca Raffaelli, Astrid Gendolla, Piero Barbanti, Cinzia Aurilia, Sabina Cevoli and 28 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05442008 (Study of Early MIDAS Reduction at 3 Months as Predictor of Long-term Erenumab Treatment in Chronic Migraine), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05442008 completednot on this map

Study of Early MIDAS Reduction at 3 Months as Predictor of Long-term Erenumab Treatment in Chronic Migraine: a Real-life, Open-label, Trial

TypeobservationalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2018 to 2021Enrolled53ConditionsMigraineArmsErenumab 70/140 mg s.c.
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Sex-specific considerations in migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  5. Observational
  6. Article
  7. Migraine in men.The journal of headache and pain · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 19 institutions in 6 countries.

Raffaele OrnelloNeuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Carlo BaraldiDepartment of Biomedical, Metabolic and Neural Sciences, School in Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Simona GuerzoniMedical Toxicology - Headache and Drug Abuse Research Center, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Giorgio LambruThe Headache Service, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom.
Matteo FuccaroThe Headache Service, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom.
Bianca RaffaelliDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Astrid GendollaPraxis Gendolla, Essen, Germany.
Piero BarbantiHeadache and Pain Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, Rome, Italy.
Cinzia AuriliaHeadache and Pain Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, Rome, Italy.
Sabina CevoliIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Valentina FavoniIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Fabrizio VernieriHeadache and Neurosonology Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Claudia AltamuraHeadache and Neurosonology Unit, Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Antonio RussoHeadache Center, Department of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marcello SilvestroHeadache Center, Department of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Elisabetta Dalla ValleHeadache Centre, Ospedale S. Antonio Abate, ASST Valle Olona, Gallarate, Italy.
Andrea MancioliHeadache Centre, Ospedale S. Antonio Abate, ASST Valle Olona, Gallarate, Italy.
Angelo RanieriHeadache Centre, Division of Neurology and Stroke Unit, "A. Cardarelli" Hospital, Naples, Italy.
Gennaro AlfieriHeadache Centre, Division of Neurology and Stroke Unit, "A. Cardarelli" Hospital, Naples, Italy.
Nina LatyshevaSechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Elena FilatovaSechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Jamie TalbotSouthwest Neurology Audit and Research Group, Department of Neurology, Derriford Hospital, Plymouth, United Kingdom.
Shuli ChengDepartment of Neurology, Alfred Health, Melbourne, VIC, Australia.
Dagny HolleDepartment of Neurology, West German Headache Center, University Hospital Essen, Essen, Germany.
Armin SchefflerDepartment of Neurology, West German Headache Center, University Hospital Essen, Essen, Germany.
Tomáš NežádalDepartment of Neurology, Military University Hospital Prague, First Faculty of Medicine Charles University, Prague, Czechia.
Dana ČtrnáctáDepartment of Neurology, Military University Hospital Prague, First Faculty of Medicine Charles University, Prague, Czechia.
Jitka ŠípkováDepartment of Neurology, Military University Hospital Prague, First Faculty of Medicine Charles University, Prague, Czechia.
Zuzana MatoušováDepartment of Neurology, Motol University Hospital Prague, First Faculty of Medicine Charles University, Prague, Czechia.
Lucia SetteNeuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Alfonsina CasalenaDepartment of Neurology, "G. Mazzini" Hospital, Teramo, Italy.
Maurizio MaddestraDepartment of Neurology, "F. Renzetti" Hospital, Chieti, Italy.
Stefano ViolaDepartment of Neurology, "S. Pio da Pietrelcina" Hospital, Chieti, Italy.
Giannapia AffaitatiHeadache Center, Geriatrics Clinic, Department of Medicine and Science of Aging and Center for Advanced Studies and Technology, G. D'Annunzio University, Chieti, Italy.
Maria Adele GiamberardinoHeadache Center, Geriatrics Clinic, Department of Medicine and Science of Aging and Center for Advanced Studies and Technology, G. D'Annunzio University, Chieti, Italy.
Francesca PistoiaNeuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Uwe ReuterThe Headache Service, Guy's and St Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom.
Simona SaccoNeuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
University of L'Aquila · ITCharles University · CZAzienda Ospedaliera Sant’Antonio Abate di Gallarate · ITCampus Bio Medico University Hospital · ITFatebenefratelli Hospital · ITGuy's and St Thomas' NHS Foundation Trust · GBIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto delle Scienze Neurologiche di Bologna · ITSechenov University · RUUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Chieti-Pescara · ITUniversity of Modena and Reggio Emilia · ITWest German Heart and Vascular Center Essen · DEAlfred Health · AUCharité - Universitätsmedizin Berlin · DEDerriford Hospital · GBMilitary University Hospital Prague · CZNational Health Service · GBOspedale "Floraspe Renzetti" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

erenumabgendermenmigrainemigraine treatmentreal-world evidence

Identifiers

PMID34975732
PMCPMC8717149
OpenAlexW4200179557

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.