Evidence map›Paper›PMID 34975542›Full record

SynthesisFrontiers in physiology2021

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis.

Chu-Yang Zeng, Zhen-Rong Zhang, Zhi-Ming Tang, Fu-Zhou Hua

3 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 119 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 9 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07283237 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Enhancing Medial Knee Pain Rehabilitation : A Clinical Trial On The Effectiveness Of Blood Flow Restriction In Combination With Targeted Exercises For Adult With Varus Deformity

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled80ConditionsKnee Osteoarthritis (Mild to Moderate, Medial Compartment)ArmsTargeted Exercise Program, Blood Flow Restriction (BFR) Training with Targeted Exercise Program
NCT07410429 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Realigning Rehab: A Randomized Controlled Trial on Specific Exercises Versus Standard Care for Medial Knee Pain and Varus Alignment

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled80ConditionsKnee Osteoarthritis (Kellgren-Lawrence Grade 1-3)ArmsConventional Knee Physical Therapy Program, Targeted Alignment-Focused Exercise Program for Varus Knee
NCT07613749 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of mechanical traction applied before versus after therapeutic exercises on clinical and functional outcomes in primary knee osteoarthritis

TypeinterventionalSponsorCairo UniversityRan2026 to 2027Enrolled63ConditionsKnee Osteoarthritis, Mechanical TractionArmsGroup A: Therapeutic exercise group, Group B: mechanical traction followed by therapeutic exercise, Group C: therapeutic exercise followed by mechanical traction
3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 9 syntheses or guidelines pooled it, 230 citations in OpenAlex.

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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chu-Yang ZengDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Zhen-Rong ZhangSchool of Rehabilitation, Capital Medical University, Beijing, China.
Zhi-Ming TangDepartment of Orthopedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.
Fu-Zhou HuaDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Second Affiliated Hospital of Nanchang University · CNCapital Medical University · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone degeneration, as well as synovitis, are the main pathological changes associated with knee osteoarthritis. Mechanical overload, inflammation, metabolic factors, hormonal changes, and aging play a vital role in aggravating the progression of knee osteoarthritis. The main treatments for knee osteoarthritis include pharmacotherapy, physiotherapy, and surgery. However, pharmacotherapy has many side effects, and surgery is only suitable for patients with end-stage knee osteoarthritis. Exercise training, as a complementary and adjunctive physiotherapy, can prevent cartilage degeneration, inhibit inflammation, and prevent loss of the subchondral bone and metaphyseal bone trabeculae. Increasing evidence indicates that exercise training can improve pain, stiffness, joint dysfunction, and muscle weakness in patients with knee osteoarthritis. There are several exercise trainings options for the treatment of knee osteoarthritis, including aerobic exercise, strength training, neuromuscular exercise, balance training, proprioception training, aquatic exercise, and traditional exercise. For Knee osteoarthritis (KOA) experimental animals, those exercise trainings can reduce inflammation, delay cartilage and bone degeneration, change tendon, and muscle structure. In this review, we summarize the main symptoms of knee osteoarthritis, the mechanisms of exercise training, and the therapeutic effects of different exercise training methods on patients with knee osteoarthritis. We hope this review will allow patients in different situations to receive appropriate exercise therapy for knee osteoarthritis, and provide a reference for further research and clinical application of exercise training for knee osteoarthritis.

Indexed as

exercise traininginflammatoryknee osteoarthritismechanismspainstrength trainingtraditional exercise

Identifiers

PMID34975542
PMCPMC8716769
OpenAlexW4200071708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.