Evidence map›Paper›PMID 34975505›Full record

ReviewFrontiers in pharmacology2021

A Glimpse in the Future of Malignant Mesothelioma Treatment.

Gaetano Pezzicoli, Mimma Rizzo, Martina Perrone, Silvia Minei, Luciano Mutti, Camillo Porta

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gaetano PezzicoliDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
Mimma RizzoA.O.U. Consorziale Policlinico di Bari, Bari, Italy.
Martina PerroneDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
Silvia MineiDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
Luciano MuttiItalian Group for Research and Therapy for Mesothelioma (GIMe), Voghera, Italy.
Camillo PortaDepartment of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.
University of Bari Aldo Moro · ITAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari · ITFondazione Gimema Onlus · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant mesothelioma (MMe) is a rare neoplasm with few therapeutic options available. The landscape of effective therapy for this disease remained unchanged in the last two decades. Recently, however, the introduction of Immune Checkpoint Inhibitors (ICIs) led to small, but nevertheless, promising improvements. However, many efforts are still needed to radically improve the prognosis of MMe. In this review, we analyze all those therapeutic strategies for MMe that are still in a preclinical or early clinical phase of development. In particular, we focus on novel antiangiogenic drugs and their possible combination with immunotherapy. Furthermore, we describe also more complex strategies such as microRNA-loaded vectors, oncolytic viruses, and engineered lymphocytes.

Indexed as

antiangiogenicsCAR-T cellsimmune checkpoint inhibitorsmesothelinmesotheliomamicroRNAoncolytic viruses

Identifiers

PMID34975505
PMCPMC8714955
OpenAlexW4200239445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.