Evidence map›Paper›PMID 34975470›Full record

ArticleFrontiers in pharmacology2021

Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain.

Xiangyu Wang, Boxuan Zhang, Xuedong Li, Xingang Liu, Songsong Wang, Yuan Xie, Jialing Pi, Zhiyuan Yang, Jincan Li, Qingzhong Jia and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  10. Review on pharmacological effects of gastrodin.Archives of pharmacal research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiangyu WangDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Boxuan ZhangDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Xuedong LiSchool of Pharmacy, Hebei Medical University, Shijiazhuang, China.
Xingang LiuDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Songsong WangDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Yuan XieDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Jialing PiDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Zhiyuan YangDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Jincan LiDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Qingzhong JiaDepartments of Pharmacology, Hebei Medical University, Shijiazhuang, China.
Yang ZhangSchool of Pharmacy, Hebei Medical University, Shijiazhuang, China.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrodin (GAS) is the main bioactive ingredient of Gastrodia, a famous Chinese herbal medicine widely used as an analgesic, but the underlying analgesic mechanism is still unclear. In this study, we first observed the effects of GAS on the vincristine-induced peripheral neuropathic pain by alleviating the mechanical and thermal hyperalgesia. Further studies showed that GAS could inhibit the current density of Na

Indexed as

gastrodinMD simulationmolecular dockingNaV1.7/NaV1.8neuropathic painvincristine

Identifiers

PMID34975470
PMCPMC8716817
OpenAlexW4200318881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.