ArticleFrontiers in aging neuroscience2021
Age- and Sex-Related Topological Organization of Human Brain Functional Networks and Their Relationship to Cognition.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Age-related degradation of cerebellar functional network topology.GeroScience · 2026Article
- The progression of sex differences in brain networks across the lifespan.bioRxiv : the preprint server for biology · 2026Article
- Social mind at rest: resting-state connectivity associated with social thought relates to friendship quality.Social cognitive and affective neuroscience · 2026Article
- Article
- EEG brain networks modulation during sleep onset: the effects of aging.GeroScience · 2025Article
- Influence of individual's age on the characteristics of brain effective connectivity.GeroScience · 2025Article
- Intersection of Brain Complexity, Functional Connectivity, and Neuropsychology: A Systematic Review.Cureus · 2025Review
- Age- and Sex-Specific Patterns in Adult Brain Network Segregation.Human brain mapping · 2025Article
- Brain Segregation and Integration Relate to Word-Finding Abilities in Older and Younger Adults.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Determinants of brain network resilience after stroke.Brain communications · 2025Article
- Neuropathology determines whether brain systems segregation benefits cognitive performance.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex differences in functional cortical organization reflect differences in network topology rather than cortical morphometry.Nature communications · 2024Article
- Aberrant brain structural-functional connectivity coupling associated with cognitive dysfunction in different cerebral small vessel disease burdens.CNS neuroscience & therapeutics · 2024Article
- Sex differences in intrinsic functional cortical organization reflect differences in network topology rather than cortical morphometry.bioRxiv : the preprint server for biology · 2023Article
- Multivariate multiscale entropy (mMSE) as a tool for understanding the resting-state EEG signal dynamics: the spatial distribution and sex/gender-related differences.Behavioral and brain functions : BBF · 2023Article
- Sex differences in multilayer functional network topology over the course of aging in 37543 UK Biobank participants.Network neuroscience (Cambridge, Mass.) · 2023Article
- Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (Frontiers in aging neuroscience · 2023Article
- Network segregation in aging females and evaluation of the impact of sex steroid hormones.Frontiers in human neuroscience · 2023Article
- A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
7 authors.
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Abstract
Age and sex associated with changes in the functional brain network topology and cognition in large population of older adults have been poorly understood. We explored this question further by examining differences in 11 resting-state graph theory measures with respect to age, sex, and their relationships with cognitive performance in 17,127 United Kingdom Biobank participants (mean = 62.83 ± 7.41 years). Age was associated with an overall decrease in the effectiveness of network communication (i.e., integration) and loss of functional specialization (i.e., segregation) of specific brain regions. Sex differences were also observed, with women showing more efficient networks, which were less segregated than in men (FDR adjusted
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