Evidence map›Paper›PMID 34975428›Full record

ArticleFrontiers in behavioral neuroscience2021

Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats.

Sophia Khom, Jacques D Nguyen, Sophia A Vandewater, Yanabel Grant, Marisa Roberto, Michael A Taffe

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. αMolecular psychiatry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Sophia KhomDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Jacques D NguyenDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
Sophia A VandewaterDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
Yanabel GrantDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
Marisa RobertoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Michael A TaffeDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
Scripps Research Institute · US

Funding

Immunopharmacotherapy for Methamphetamine AddictionR01DA024705 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAFFE, MICHAEL A. · 2008 to 2018
$4.4M
Dissecting the Abuse Liability of Synthetic Cathinone StimulantsR01DA042211 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MICHAEL A. TAFFE · 2016 to 2026
$3.6M
Determinants of transition states in MDMA self-administrationR01DA024105 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI TAFFE, MICHAEL A. · 2011 to 2015
$1.9M
Elucidating behavior and neural circuits underlying opioid addiction and dependenceR00DA047413 · NIDA · BAYLOR UNIVERSITY · PI NGUYEN, JACQUES DUCHUY · 2023 to 2025
$747k
Elucidating behavior and neural circuits underlying opioid addiction and dependenceK99DA047413 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, JACQUES DUCHUY · 2019 to 2022
$558k
NIDA NIH HHS K99 DA047413NIDA NIH HHS R00 DA047413NIDA NIH HHS R01 DA024105NIDA NIH HHS R01 DA024705NIDA NIH HHS R01 DA042211
6 · The paper itself

Abstract

Male rats escalate intravenous self-administration of entactogen psychostimulants, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxymethamphetamine (MDMA) under extended access conditions, as with typical psychostimulants. Here, we investigated whether female rats escalate self-administration of methylone, 3,4-methylenedioxypentedrone (pentylone), and MDMA and then studied consequences of MDMA and pentylone self-administration on GABA

Indexed as

central amygdalaelectrophysiologyinhibitory synaptic transmissionintravenous self-administrationMDMAmethylonepentylone

Identifiers

PMID34975428
PMCPMC8716434
OpenAlexW4200256404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.