Evidence map›Paper›PMID 34975322›Full record

ArticleInternational journal of biological sciences2022

RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma.

Yingyue Cao, Jianxiong Geng, Xin Wang, Qingwei Meng, Shanqi Xu, Yaoguo Lang, Yongxu Zhou, Lishuang Qi, Zijie Wang, Zixin Wei and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway.International journal of molecular sciences · 2025
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  13. Investigation ofHeliyon · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Yingyue CaoDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Jianxiong GengDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Xin WangDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Qingwei MengDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Shanqi XuDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Yaoguo LangDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Yongxu ZhouDepartment of hepatopancreatobiliary surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, 150040, China.
Lishuang QiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150040, China.
Zijie WangDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Zixin WeiDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Yan YuDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Shi JinNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Perking Union Medical College, Shenzhen, 518116, China.
Bo PanDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Haping Road No 150, Harbin 150040, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA-binding motif protein 10 (RBM10), one of the members of the RNA-binding protein (RBP) family, has a tumor suppressor role in multiple cancers. However, the functional role of RBM10 in lung adenocarcinoma (LUAD) and the underlying molecular mechanism remains unclear. In this study, we observed that RBM10 is significantly downregulated in LUAD tissues compared with normal tissues. Low RBM10 expression is significantly associated with poor outcome of LUAD patients.

Indexed as

Wnt Signaling PathwayAdenocarcinoma of LungAnimalsbeta CateninCarcinogenesisCell Line, TumorCell MovementCell ProliferationDown-RegulationFemaleHumansLung NeoplasmsMiceMice, NudeRNA-Binding ProteinsXenograft Model Antitumor Assaysbeta CateninRBM10 protein, humanRBM10 protein, mouseRNA-Binding ProteinsCTNNBIP1lung adenocarcinomaprogressionRBM10Wnt/β-catenin pathway

Identifiers

PMID34975322
PMCPMC8692145
OpenAlexW3212363607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.