Evidence map›Paper›PMID 34975320›Full record

ArticleInternational journal of biological sciences2022

GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway.

Jian Lu, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. The roles of free-fatty acid receptors in the pathophysiology of renal disorders.The Journal of pharmacology and experimental therapeutics · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Autophagy and Mitophagy in Diabetic Kidney Disease-A Literature Review.International journal of molecular sciences · 2025
    Review
  13. Review
  14. Article
  15. Molecular mechanism of renal lipid accumulation in diabetic kidney disease.Journal of cellular and molecular medicine · 2024
    Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Jian LuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Pei Pei ChenInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Jia Xiu ZhangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xue Qi LiInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Gui Hua WangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Ben Yin YuanInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Si Jia HuangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xiao Qi LiuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Ting Ting JiangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Meng Ying WangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Wen Tao LiuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xiong Zhong RuanJohn Moorhead Research Laboratory, Department of Renal Medicine, University College London (UCL) Medical School, Royal Free Campus, London, NW3 2PF, UK.
Bi Cheng LiuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Kun Ling MaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Zhongda Hospital Southeast University · CNUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Lipid MetabolismMAP Kinase Signaling SystemAnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesDisease Models, AnimalEarly Growth Response Protein 1MicePodocytesReceptors, G-Protein-CoupledReceptors, LDLEarly Growth Response Protein 1Egr1 protein, mouseFfar2 protein, mouseReceptors, G-Protein-CoupledReceptors, LDLautophagydiabetic nephropathyGPR43lipotoxicitylow-density lipoprotein receptorpodocytes

Identifiers

PMID34975320
PMCPMC8692141
OpenAlexW3211920311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.