Evidence map›Paper›PMID 34975216›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2022

Modulation of mTOR signaling by radiation and rapamycin treatment in canine mast cell cancer cells.

Morla Phan, Changseok Kim, Anthony Mutsaers, Valerie Poirier, Brenda Coomber

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Morla PhanDepartment of Biomedical Sciences (Phan, Mutsaers, Coomber) and Department of Clinical Studies (Kim, Mutsaers, Poirier), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Changseok KimDepartment of Biomedical Sciences (Phan, Mutsaers, Coomber) and Department of Clinical Studies (Kim, Mutsaers, Poirier), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Anthony MutsaersDepartment of Biomedical Sciences (Phan, Mutsaers, Coomber) and Department of Clinical Studies (Kim, Mutsaers, Poirier), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Valerie PoirierDepartment of Biomedical Sciences (Phan, Mutsaers, Coomber) and Department of Clinical Studies (Kim, Mutsaers, Poirier), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Brenda CoomberDepartment of Biomedical Sciences (Phan, Mutsaers, Coomber) and Department of Clinical Studies (Kim, Mutsaers, Poirier), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapamycin has been reported to reduce cancer cell survival in certain tumors following radiation therapy, but the mechanisms driving this phenomenon are unclear. Rapamycin inhibits mTOR signaling, a pathway responsible for several essential cell functions. The objective of this study was to investigate the effects of rapamycin and radiation on the activation and inhibition of mTOR signaling and the relationship between mTOR signaling and DNA damage response

Indexed as

Dog DiseasesMast CellsSignal TransductionSirolimusTOR Serine-Threonine KinasesAnimalsCell Line, TumorDogsSirolimusTOR Serine-Threonine Kinases

Identifiers

PMID34975216
PMCPMC8697317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.