ReviewIndian journal of pharmacology
Nicolau syndrome following subcutaneous glatiramer acetate injection: A case report and review of the literature.
Review in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- An Unusual Presentation of Nicolau Syndrome in the Upper Limb: A Case Report from Northern Ecuadorian Amazonia.Journal of clinical medicine · 2026Article
- Nicolau syndrome in a pediatric patient after corticosteroid injection: a case report and review of the literature.Journal of medical case reports · 2025Review
- Nicolau syndrome: A case of ischemic necrosis after subcutaneous immunotherapy.The journal of allergy and clinical immunology. Global · 2025Article
- Nicolau syndrome following glatiramer acetate for multiple sclerosis: Case and review of reports.Annals of clinical and translational neurology · 2024Article
- Thermal imaging of local skin temperature as part of quality and safety assessment of injectable drugs.Heliyon · 2024Article
- Nicolau syndrome after intramuscular injection of methocarbamol: A rare case report.Toxicology reports · 2023Article
- Adverse side effects of Glatiramer acetate and Interferon beta-1a in patients with multiple sclerosis: A systematic review of case reports.Current journal of neurology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicolau syndrome is a rare serious drug reaction associated with the administering various injectable medications. It is often characterized by an acute and severe pain accompanying erythema that tends to rapidly evolve into the livedoid reticular or hemorrhagic patches and less commonly to ulcers and skin necrosis. Herein, we report a 34-year-old woman who presented with painful, tender discoloration over her abdominal skin following subcutaneous glatiramer acetate injection. Since the patient was diagnosed with multiple sclerosis 18 months ago, she had been on treatment with subcutaneous glatiramer acetate injections thrice weekly. The patient was diagnosed with Nicolau syndrome clinically and histopathologically. After 15-day treatment with topical betamethasone valerate and mucopolysaccharide polysulfate cream twice daily, the lesion completely regressed with only minimal hypopigmented irregular scarring. Nicolau syndrome should be considered in patients with severe pain, tenderness, and redness localized at the injection site following glatiramer subacetate.
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Registered trials
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